Understanding young onset colorectal cancer
Young Onset Gastrointestinal Cancer Prospective Registry
Memorial Sloan Kettering Cancer Center · NCT04489238
This study is trying to gather information from people with colorectal cancer to see how cases in younger patients under 50 are different from those diagnosed after 50.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1366 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Memorial Sloan Kettering Cancer Center (other) |
| Drugs / interventions | chemotherapy, immunotherapy, radiation |
| Locations | 8 sites (Basking Ridge, New Jersey and 7 other locations) |
| Trial ID | NCT04489238 on ClinicalTrials.gov |
What this trial studies
This observational study aims to create a comprehensive database to better understand young onset colorectal cancer, defined as cases diagnosed in individuals under 50 years old. Researchers will collect information through a risk factor questionnaire from participants diagnosed with gastrointestinal cancer and those diagnosed with colorectal adenocarcinoma over the age of 50. The goal is to analyze similarities and differences between young onset colorectal cancer and cases diagnosed later in life, facilitating current and future research in this area.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 18-49 diagnosed with gastrointestinal cancer or those aged 50 and older diagnosed with colorectal adenocarcinoma.
Not a fit: Patients with known hereditary colorectal cancer syndromes or a history of inflammatory bowel disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of young onset colorectal cancer, potentially enhancing patient outcomes.
How similar studies have performed: While this approach is focused on a specific age group, similar registry studies have shown success in understanding cancer epidemiology and risk factors.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Participant Inclusion Criteria for database and questionnaire (YOGI) * Histological or cytological diagnosis of gastrointestinal cancer * 18 - 49 years old at time of consent * No Known hereditary CRC or other cancer predisposition syndrome (stool collection cohort only) * No history of inflammatory bowel disease (stool collection cohort only) * No prior diagnosis of gastrointestinal cancer (stool collection cohort only) Participant Inclusion Criteria for database and questionnaire (Controls) * Histological or cytological diagnosis of colorectal adenocarcinoma * No previous treatment for CRC (including surgery, chemotherapy, immunotherapy or radiation) * Age 50 or older at time of consent * No Known hereditary CRC or other cancer predisposition syndrome * No history of inflammatory bowel disease * No prior diagnosis of CRC
Where this trial is running
Basking Ridge, New Jersey and 7 other locations
- Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States (RECRUITING)
- Memorial Sloan Kettering Monmouth — Middletown, New Jersey, United States (RECRUITING)
- Memorial Sloan Kettering Bergen — Montvale, New Jersey, United States (RECRUITING)
- Memorial Sloan Kettering Cancer Center @ Commack — Commack, New York, United States (RECRUITING)
- Memorial Sloan Kettering Westchester — Harrison, New York, United States (RECRUITING)
- MSK at Ralph Lauren — New York, New York, United States (RECRUITING)
- Memorial Sloan Kettering Cancer Center — New York, New York, United States (RECRUITING)
- Memorial Sloan Kettering Nassau — Rockville Centre, New York, United States (RECRUITING)
Study contacts
- Principal investigator: Andrea Cercek, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Andrea Cercek, MD
- Email: cerceka@mskcc.org
- Phone: 646-888-4189
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Colorectal Cancer, Colorectal Carcinoma, young onset colorectal cancer, colorectal registry, 20-315, Memorial Sloan Kettering Cancer Center