Culturally adapted online genetic counseling and testing education for African American cancer survivors
A Community-Engaged Approach to Culturally Adapting an Intervention to Increase Uptake of Genetic Testing Among African American Cancer Survivors
We will test a culturally adapted online genetic counseling program to see if it increases genetic counseling and genetic testing among African American breast, prostate, and colorectal cancer survivors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 85 (estimated) |
| Ages | 20 Years to 79 Years |
| Sex | All |
| Sponsor | Barbara Ann Karmanos Cancer Institute Academic / other |
| Locations | 1 site (Detroit, Michigan) |
| Trial ID | NCT07436078 on ClinicalTrials.gov |
What this trial studies
Investigators will work with community stakeholders and clinical genetic professionals to adapt and refine an online genetic counseling education program tailored for at-risk African American cancer survivors. Participants enrolled in the Detroit ROCS cohort who receive care at Karmanos will provide consent and complete questionnaires before the online intervention, immediately after, and at 3 months. The primary aim is to measure whether the culturally adapted program increases uptake of genetic counseling and genetic testing. The team will also collaborate with community leaders to identify barriers and create a roadmap for wider dissemination of the intervention.
Who should consider this trial
Good fit: Ideal candidates are Detroit ROCS participants diagnosed with primary breast, prostate, or colorectal cancer on or after 1/1/2013 who receive care at Karmanos Cancer Institute and meet one or more NCCN criteria for genetic testing.
Not a fit: People not enrolled in Detroit ROCS, not receiving care at Karmanos, who do not meet NCCN testing criteria, or who have already completed genetic counseling and testing are unlikely to benefit from this intervention.
Why it matters
Potential benefit: If successful, the program could increase identification of hereditary cancer risk among African American survivors by raising uptake of genetic counseling and testing, which may inform treatment and family risk management.
How similar studies have performed: Some prior work shows culturally tailored education can improve genetic testing uptake in underserved groups, but online culturally adapted genetic counseling specifically for African American cancer survivors is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants enrolled in Detroit Research on Cancer Survivors (Detroit ROCS) * Diagnosis of Primary Breast, prostate, or colorectal cancer on or after 1/1/2013 * have received or currently receiving care at Karmanos Cancer Institute * meet one or more of the National Comprehensive Cancer Network (NCCN) guidelines for cancer genetic testing as described below Female breast 1. personal diagnosis at age ≤50 2. personal history of the triple-negative subtype 3. at least 1 close (first- or second-degree) relative diagnosed with breast cancer at age \<50 4. at least 1 close relative diagnosed with ovarian cancer 5. 2+ close relatives diagnosed with breast or prostate cancer 6. age \<50 AND another primary breast cancer at any age 7. 2+ primary breast cancers at any age OR Prostate 1. personal history of high-risk or very high-risk prostate cancer 2. personal history of regional or metastatic prostate cancer 3. personal history of less than high-risk prostate cancer with a suggestive family history (i.e., father or brother or multiple relatives with prostate cancer diagnosed at age \<60; at least 1 relative with breast, ovarian, or pancreatic cancer; or at least 1 relative with colorectal, ovarian, pancreatic, or kidney cancer) OR Colorectal 1. personal diagnosis at age ≤50 2. at least 1 close relative diagnosed with HNPCC at age \<50 3. at least 2 close relatives diagnosed with an HNPCC cancer at any age 4. colorectal and \>=1 primary endometrial, ovarian, gastric, pancreatic, or prostate Exclusion Criteria: * Previous genetic counseling and/or testing
Where this trial is running
Detroit, Michigan
- Karmanos Cancer Institute — Detroit, Michigan, United States (Recruiting)
Study contacts
- Principal investigator: Felicity WK Harper, Ph.D — Barbara Ann Karmanos Cancer Institute
- Study coordinator: Jasminder Phalore, MPH
- Email: phalorej@karmanos.org
- Phone: 313-576-9735
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.