Understanding genetic factors in cognitive decline before dementia starts
Official title: Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset
Funded at University of Texas at Austin · NIH-10891784 · Data updated 2026-11-12
This study is looking at how our genes might affect memory and thinking problems as we get older, especially for people at risk of Alzheimer's and similar conditions, to help find ways to spot these issues earlier and improve care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $655,978 |
| NIH project number | 4R01AG073593-02 |
| Project ID | NIH-10891784 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old who are at risk for Alzheimer's Disease or related dementias.
✕Less likely to help
Patients who are already diagnosed with advanced Alzheimer's Disease or related dementias may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to cognitive decline associated with aging, particularly focusing on Alzheimer's Disease and related dementias. By utilizing advanced genome-wide association studies (GWAS), the project aims to identify genetic variants that may influence the risk of developing these conditions. The research addresses the challenge of diagnosing cognitive decline early, as many individuals may experience significant neurodegeneration long before clinical symptoms appear. Through this approach, the study seeks to uncover the biological pathways involved in cognitive changes, potentially leading to earlier interventions.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for individuals at risk of Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research using genome-wide association studies has shown promise in identifying genetic risk factors for Alzheimer's Disease, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Tucker-Drob, Elliot Max — University of Texas at Austin
- Study coordinator: Tucker-Drob, Elliot Max
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.