Personalized ECT for better depression treatment outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effects of individualized amplitude ECT versus fixed 800 mA ECT on depression and cognitive outcomes in older adults. Participants will undergo baseline assessments before receiving ECT treatments, with evaluations conducted at multiple time points to measure antidepressant response and cognitive function. The study hypothesizes that personalized amplitude adjustments will lead to improved treatment efficacy and reduced cognitive impairment compared to traditional fixed dosing. A total of 50 subjects will be enrolled, with assessments focusing on neuroplasticity and clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of major depressive disorder or bipolar II
* Clinical indications for ECT with right unilateral electrode placement

Exclusion Criteria:

* Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease)
* Other psychiatric conditions (e.g., schizophrenia, bipolar I disorder)
* Current drug or alcohol use disorder (except for nicotine)
* Contraindications to MRI.

Where it's running

• University of New Mexico Health Science Center
  Albuquerque, New Mexico, United States Recruiting

Study contacts

• Principal investigator: Chris Abbott, MD — University of New Mexico
• Study coordinator: Chris Abbott, MD
• Email: cabbott@salud.unm.edu
• Phone: 5052720406

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.