Improving brain and heart health through a specific diet
Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes: Examining the Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay(MIND) on Cognitive Performance, Metabolic Health and Lifestyle Outcomes Using Advanced Machine Learning Strategies
This study is testing if following the MIND diet can improve brain and heart health in middle-aged adults compared to a standard healthy diet.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 45 Years to 64 Years |
| Sex | All |
| Sponsor | University of Illinois at Urbana-Champaign Academic / other |
| Locations | 1 site (Urbana, Illinois) |
| Trial ID | NCT06605898 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to determine if adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet enhances cognitive performance and heart health compared to a standard healthy diet in middle-aged adults. Participants will be divided into three groups: one selected through predictive analytics, one following the MIND diet without pre-selection, and a control group on a standard healthy diet. Over 12 weeks, participants will receive daily meals and smoothies delivered to their homes and will complete various assessments, including memory tests and health evaluations. The study seeks to understand the effectiveness of the MIND diet and the role of predictive analytics in identifying those who may benefit most.
Who should consider this trial
Good fit: Ideal candidates are middle-aged adults aged 45-64 who are cognitively intact and have no significant health issues or dietary restrictions.
Not a fit: Patients with neurological diseases, significant gastrointestinal issues, or those currently on specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved dietary recommendations that enhance cognitive and cardiovascular health in middle-aged adults.
How similar studies have performed: Other studies have shown promising results with dietary interventions aimed at improving cognitive and heart health, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 45-64 years of age * 20/20 or corrected vision * No food allergies or intolerances * Not pregnant, lactating, or have given birth in the past 12 months * Do not smoke, use tobacco, or abuse drugs * Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer * Not currently taking oral hypoglycemic agents, or insulin * No history of malabsorptive or bariatric surgery * Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome) * Able to consume the study meals * Not enrolled in another dietary, exercise, or medication study during the study. Exclusion Criteria: * Non-consent of participant * Above 64 or below 45 years of age * Vision not 20/20 or corrected * Food allergies or intolerances * Pregnant, lactating, or have given birth in the past 12 months * Smoke, use tobacco, or abuse drugs * Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer * Currently taking oral hypoglycemic agents or insulin * History of malabsorptive or bariatric surgery * Cognitively impaired and/or prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome) * Unable to consume the study meals * Concurrent enrollment in another dietary, exercise, or medication study
Where this trial is running
Urbana, Illinois
- University of Illinois at Urbana-Champaign — Urbana, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Naiman Khan, PhD — University of Illinois Urbana-Champaign
- Study coordinator: Naiman Khan, PhD
- Email: nakhan2@illinois.edu
- Phone: 2173001667
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.