Improving brain and heart health through a specific diet

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to determine if adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet enhances cognitive performance and heart health compared to a standard healthy diet in middle-aged adults. Participants will be divided into three groups: one selected through predictive analytics, one following the MIND diet without pre-selection, and a control group on a standard healthy diet. Over 12 weeks, participants will receive daily meals and smoothies delivered to their homes and will complete various assessments, including memory tests and health evaluations. The study seeks to understand the effectiveness of the MIND diet and the role of predictive analytics in identifying those who may benefit most.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 45-64 years of age
* 20/20 or corrected vision
* No food allergies or intolerances
* Not pregnant, lactating, or have given birth in the past 12 months
* Do not smoke, use tobacco, or abuse drugs
* Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer
* Not currently taking oral hypoglycemic agents, or insulin
* No history of malabsorptive or bariatric surgery
* Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome)
* Able to consume the study meals
* Not enrolled in another dietary, exercise, or medication study during the study.

Exclusion Criteria:

* Non-consent of participant
* Above 64 or below 45 years of age
* Vision not 20/20 or corrected
* Food allergies or intolerances
* Pregnant, lactating, or have given birth in the past 12 months
* Smoke, use tobacco, or abuse drugs
* Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer
* Currently taking oral hypoglycemic agents or insulin
* History of malabsorptive or bariatric surgery
* Cognitively impaired and/or prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome)
* Unable to consume the study meals
* Concurrent enrollment in another dietary, exercise, or medication study

Where it's running

• University of Illinois at Urbana-Champaign
  Urbana, Illinois, United States Recruiting

Study contacts

• Principal investigator: Naiman Khan, PhD — University of Illinois Urbana-Champaign
• Study coordinator: Naiman Khan, PhD
• Email: nakhan2@illinois.edu
• Phone: 2173001667

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Home-based nutrition intervention for Latinx families with preschool children

  This study is testing a home-based nutrition program to see if it can help low-income Latinx families with preschool children eat healthier.

  Recruiting Brown University · Providence, Rhode Island · NCT06099288

• Early Cognitive Interventions in Digital Format for Cancer Survivors: Home-Based Training for CRCI

  Two digital cognitive training programs done at home (one computerized, one virtual reality) are tested to see if they help adults with cancer-related cognitive changes more than usual care.

  Recruiting at 3 sites Biogipuzkoa Health Research Institute · Bilbao, Bizkaia and 2 other locations · NCT07729969

• Healthy Options At Pantries prompts healthier online pantry choices

  A digital nudge called HOAP is tested in online food pantries to see if it helps shoppers pick healthier items.

  Recruiting Northwestern University · Chicago, Illinois · NCT07729436

• Early cognitive changes after same-day hip or knee replacement

  This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.

  Recruiting Odense University Hospital · Svendborg · NCT07598552

• Bioavailability of broccoli extract supplements in healthy adults

  This study tests how much glucoraphanin and sulforaphane from three broccoli extract versions are absorbed and excreted in healthy adults aged 18–60.

  Recruiting Oregon State University · Corvallis, Oregon · NCT07564674

• Integrated Data for Healthy Aging in Taiwan

  This project tests whether combining clinical data, genomics, and microbiome information can help identify early aging-related risks in adults 40 and older in Taiwan.

  Recruiting at 2 sites Chang Gung Memorial Hospital · Taipei and 1 other locations · NCT07414680

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.