Integrated Data for Healthy Aging in Taiwan

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational program builds a comprehensive, local health database by integrating clinical records, functional assessments, genomics, metabolomics, and gut microbiome data from adults aged 40+ in Taiwan. Longitudinal multi-omics analyses will examine metabolic dynamics and their links to aging-related conditions, including sarcopenia, sleep disturbance, cognitive change, and psychosocial factors. The study aims to validate biomarkers and develop predictive models to support early detection and personalized interventions for healthy aging. It uses existing cohorts and hospital records to create a platform for precision aging research and potential preventative strategies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willing to sign a written participant consent form.
* Males or females aged 40 or above who have participated in the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging (Pilot Project)," the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging" master planner, or the "Integrated Systematic Medical Information to Explore Solutions for Healthy Aging" project (not subject to exclusion criteria).
* Males or females aged 40-59 who have participated in health checkups for employees of Chang Gung Memorial Hospital, Formosa Plastics Group, or Chang Gung University.
* Those with a medical record of more than one year at Chang Gung Memorial Hospital.
* Those who have resided in Taiwan for more than 180 days in the past year.

Exclusion Criteria:

* Individuals with severe organ abnormalities, such as: heart failure (NYHA Fc ≥ III), chronic obstructive pulmonary disease (hospitalization/emergency room visit or medication adjustment within the past month due to disease worsening), decompensated cirrhosis, hemodialysis, or currently undergoing cancer treatment.
* Individuals with a history of severe autoimmune diseases.
* Individuals with a preliminary cognitive and mental assessment score of \<26 on the Mini-Mental State Examination (MMSE) or ≥5 on the Generalized Depression Scale (GDS).
* Individuals (who agree to undergo brain MRI) who are deemed unsuitable for MRI after evaluation (e.g., those with pacemakers, cochlear implants, or spatial phobia).
* Individuals who have taken antibiotics within the past month.
* Individuals whose hearing, vision, or cognitive impairments affect communication.
* Individuals unable to stand or walk (with a walking aid) or with unsteady gait when walking.
* Those who have undergone follow-up outpatient assessments that may affect cognitive function, including but not limited to stroke, Parkinson's syndrome, Parkinson's dementia, epilepsy, brain tumor, or a history of mental illness such as schizophrenia, severe depression, bipolar disorder, alcohol or drug abuse, or a history of loss of consciousness due to severe head trauma.
* Those currently diagnosed with depression and undergoing treatment.
* Those with a past medical history confirming dementia, depression, etc..
* Those deemed unsuitable by a physician.

Where it's running

• Taipei Chang Gung Memorial Hospital
  Taipei, Taiwan Recruiting
• Taoyuan Chang Gung Memorial Hospital
  Taoyuan, Taiwan Recruiting

Study contacts

• Study coordinator: JI-TSENG FANG, Professor
• Email: fangjits@cgmh.org.tw
• Phone: +886-3-3281200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.