Understanding brain receptors in cocaine use disorder
Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.
This research explores a specific brain receptor, called M1, to find new ways to help people with cocaine use disorder.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11126696 on NIH RePORTER |
What this research studies
We know that cocaine use disorder is a serious health concern, and there aren't many effective treatments available. This project looks into a specific brain system, the M1 receptor, which is very important for how our brains work and is found in areas linked to addiction. Previous laboratory work suggests that activating M1 receptors might reduce the rewarding effects of cocaine, and that people who use cocaine regularly may have fewer of these receptors. By understanding how M1 receptors function in individuals with cocaine use disorder, we hope to uncover new targets for medication development.
Who could benefit from this research
Good fit: Ideal candidates for future related studies would be individuals diagnosed with cocaine use disorder.
Not a fit: Patients without cocaine use disorder would not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective medications for individuals struggling with cocaine use disorder.
How similar studies have performed: While the specific approach of targeting M1 receptors for cocaine use disorder is innovative, preclinical evidence consistently shows a link between M1 receptor function and the effects of cocaine.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Angarita, Gustavo Adolfo — Yale University
- Study coordinator: Angarita, Gustavo Adolfo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.