Investigating how cocaine use affects brain health in people with HIV
Single Cell Transcriptomics of the Cocaine Use Disorder in the Context of HIV
This study is looking at how cocaine use affects brain health in people living with HIV, and it aims to understand the changes in the brain that can lead to thinking and memory problems, so if you're part of this group, your participation could help find better treatments for both HIV and drug use issues.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11117172 on NIH RePORTER |
What this research studies
This research explores the impact of cocaine use on brain health in individuals living with HIV, focusing on how it disrupts the blood-brain barrier and contributes to neurocognitive disorders. By analyzing single-cell transcriptomics, the study aims to understand the molecular changes that occur in the brain due to the combined effects of HIV and cocaine. Patients may be involved in providing biological samples to help researchers identify specific cellular responses and mechanisms at play. The findings could lead to better treatment strategies for those affected by both HIV and substance use disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of cocaine use.
Not a fit: Patients who do not have HIV or a history of cocaine use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive impairments in patients with HIV who use cocaine.
How similar studies have performed: While the specific combination of HIV and cocaine use in this context is less explored, related studies have shown that understanding the molecular impacts of substance use on brain health can lead to significant advancements in treatment.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Cheng, Christine — University of California, San Diego
- Study coordinator: Cheng, Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.