Using Semaglutide to Help Treat Cocaine Use Disorder
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder: a Pilot Mechanistic Study
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11104610
This study is looking at whether semaglutide, a medication usually used for diabetes and weight loss, can help people with cocaine addiction by improving their treatment and making therapy more effective.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11104610 on ClinicalTrials.gov |
What this research studies
This research investigates the potential of semaglutide, a medication typically used for diabetes and obesity, to treat cocaine use disorder (CUD). The study aims to understand how this drug can affect brain pathways related to addiction and enhance the effectiveness of behavioral therapies like cognitive-behavioral therapy. By examining its impact on cocaine-related behaviors in both animal models and humans, the research seeks to provide new pharmacological options for individuals struggling with CUD. If successful, this could lead to improved treatment strategies for those affected by cocaine addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with cocaine use disorder who may benefit from additional treatment options beyond traditional behavioral therapies.
Not a fit: Patients who are not struggling with cocaine use disorder or those who do not meet the criteria for participation in the study may not receive any benefit.
Why it matters
Potential benefit: If successful, this research could provide a new pharmacological treatment option for individuals with cocaine use disorder, potentially improving recovery outcomes.
How similar studies have performed: While the use of GLP-1 receptor agonists in treating cocaine use disorder is a novel approach, preliminary animal studies have shown promising results, indicating potential for success in human trials.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YAMMINE, LUBA — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: YAMMINE, LUBA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus