Clonidine to reduce craving in hospitalized people with cocaine or crack use disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized interventional study in hospitalized adults with DSM-5 cocaine or crack use disorder at the Instituto Perdizes (Hospital das Clínicas, University of São Paulo). Participants are randomized to receive clonidine 0.1 mg every 12 hours or clonazepam 0.25 mg every 12 hours under nursing supervision for the first two weeks, followed by a two-week washout. Vital signs are monitored three times daily to track medication effects such as bradycardia or hypotension. The primary outcome is the change in self-reported cocaine craving from admission to two weeks measured by a visual analog scale.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalized in the adult Alcohol and Drugs ward of the Perdizes Institute (IPer) at the Hospital das Clínicas, University of São Paulo Medical School
* DSM-5 criteria for cocaine and/or crack use disorder
* Voluntarily seeking treatment
* Must be able to swallow pills

Exclusion Criteria:

* Inability to read and/or understand the study questionnaires
* benzodiazepine use disorder
* opioid use disorder
* alcohol use disorder

Where it's running

• Instituto Perdizes
  São Paulo, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Dangela Lassi — University of São Paulo General Hospital
• Study coordinator: Dangela Lassi
• Email: dangela.lassi@hc.fm.usp.br
• Phone: +551138032802

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.