Investigating brain changes in people with cocaine use disorder
Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET Study
This study is looking at how cocaine use changes the brain's connections, especially in an area that helps with decision-making, to better understand cravings and behaviors in people with cocaine addiction, and it involves using a special imaging technique to see these changes in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11078350 on NIH RePORTER |
What this research studies
This research examines how cocaine use affects the brain's synaptic plasticity, particularly focusing on changes in synaptic density in the medial prefrontal cortex. Using a novel imaging technique called positron emission tomography (PET) with a special radiotracer, the study aims to visualize and measure synaptic density in individuals with cocaine use disorder. By understanding these brain changes, the research seeks to uncover the mechanisms behind cravings and compulsive behaviors associated with cocaine addiction. Participants will be monitored for their cocaine use and abstinence to correlate these behaviors with brain imaging results.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cocaine use disorder who are currently using cocaine or have recently abstained from it.
Not a fit: Patients who do not have a history of cocaine use or those with other substance use disorders unrelated to cocaine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals struggling with cocaine addiction.
How similar studies have performed: Previous research has shown promising results in understanding synaptic changes related to cocaine use, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Angarita, Gustavo Adolfo — Yale University
- Study coordinator: Angarita, Gustavo Adolfo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.