Investigating brain receptors related to cocaine use disorder
Official title: Assessing central muscarinic acetylcholine type-1 receptors in cocaine use disorder with 11C-LSN3172176.
Funded at Yale University · NIH-11055793 · Data updated 2026-11-12
This study is looking at how certain brain receptors are involved in cocaine addiction to find new ways to help people who are struggling with this issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | April 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $830,720 |
| NIH project number | 4R33DA053592-03 |
| Project ID | NIH-11055793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cocaine use disorder who are seeking treatment options.
✕Less likely to help
Patients who do not have a diagnosis of cocaine use disorder or those who are not currently using cocaine may not benefit from this research.
What this research studies
This research focuses on understanding the role of muscarinic acetylcholine type-1 receptors in individuals with cocaine use disorder (CUD). By examining how these receptors function in the brain, particularly in areas associated with addiction, the study aims to uncover new therapeutic approaches for treating CUD. The research employs advanced imaging techniques to assess receptor activity and its relationship with cocaine use patterns. Through this innovative approach, the study seeks to provide insights that could lead to more effective treatments for those struggling with addiction.
Why it matters
Potential benefit: If successful, this research could lead to new pharmacotherapies that effectively reduce cravings and improve treatment outcomes for individuals with cocaine use disorder.
How similar studies have gone: Previous research has shown promising results in targeting brain receptors for addiction treatment, suggesting that this approach may lead to significant advancements in therapy for cocaine use disorder.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Angarita, Gustavo Adolfo — Yale University
- Study coordinator: Angarita, Gustavo Adolfo
Related research
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Understanding how early life stress and cocaine exposure shape brain and behavior in adults
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-
Psilocybin-Assisted ACT for Co-Occurring Cocaine Use Disorder and Major Depressive Disorder
A new treatment combines psilocybin with Acceptance and Commitment Therapy to help people who have both cocaine use disorder and major depressive disorder.
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Cholinergic Dysregulation and Cognitive Flexibility in Cocaine Use Disorder
A research study explores how cocaine changes brain signaling to affect flexible thinking and decision-making in people with cocaine use disorder.
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Oligonucleotide therapy to help cocaine use disorder reach the brain
A new ASO-based approach aims to deliver gene-targeting therapy across the blood–brain barrier to help people with cocaine use disorder.
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Accelerated TMS for Cocaine Use Disorder
A new, faster brain-stimulation treatment is being tested to help adults with cocaine use disorder reduce cravings and use.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.