NTX-2001: A TAAR1-based treatment to help adults with Cocaine Use Disorder
Official title: NTX-2001, a trace amine-associated receptor 1 (TAAR1) partial agonist, for the treatment of Cocaine Use Disorder
Funded at Newleos Therapeutics, INC. · NIH-11390841 · Data updated 2026-11-12
A new drug candidate, NTX-2001, aims to help adults with Cocaine Use Disorder by reducing cravings and cocaine use with minimal disruption to normal brain function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Newleos Therapeutics, INC. NIH-funded |
| Lab location | 1 site (Hopkinton, United States) |
| Project start | September 15, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $3,097,247 |
| NIH project number | 1UG3DA066264-01 |
| Project ID | NIH-11390841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 and older with Cocaine Use Disorder who are seeking treatment and are willing to participate in a pharmacotherapy trial.
✕Less likely to help
People without Cocaine Use Disorder or those unable to participate in a pharmacological trial may not benefit.
What this research studies
If you or someone you know struggles with Cocaine Use Disorder, this project tests a new medicine called NTX-2001 that targets a specific brain receptor to reduce cravings and use. The study will assess safety and tolerability while checking for signals that the drug can help people stay abstinent longer and feel fewer cravings, especially during high-dopamine moments. The researchers plan to monitor how well the drug works in real-world settings and how it interacts with existing treatments for addiction. The ultimate goal is to offer a pharmacological option that complements behavioral therapies and supports lasting recovery.
Why it matters
Potential benefit: If successful, NTX-2001 could become an approved treatment that helps people reduce cocaine use and cravings.
How similar studies have gone: TAAR1-targeted therapies have shown promise in preclinical studies for reducing cocaine-seeking behavior, but human data are still emerging.
Where this research is happening
-
Newleos Therapeutics, INC.
Hopkinton, United States Active
Researchers
- Principal investigator: Hopkins, Seth C — Newleos Therapeutics, INC.
- Study coordinator: Hopkins, Seth C
Related research
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Oligonucleotide therapy to help cocaine use disorder reach the brain
A new ASO-based approach aims to deliver gene-targeting therapy across the blood–brain barrier to help people with cocaine use disorder.
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Accelerated TMS for Cocaine Use Disorder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.