Cue-reactivity incubation and cognitive reappraisal in cocaine use disorder
Official title: Cognitive Reappraisal for Mitigating Incubation of Cocaine Cue-Reactivity
Run by Icahn School of Medicine at Mount Sinai · NCT07091877 · Data updated 2026-11-12
This project will see if practicing cognitive reappraisal reduces cue-triggered brain responses and cravings in people with cocaine use disorder who are early in abstinence.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 252 (estimated) |
| Sponsor | Icahn School of Medicine at Mount Sinai Academic / other |
| Locations | 1 site (New York, New York) |
| Status | Recruiting |
| Started | December 15, 2024 |
| Main results expected | April 30, 2028 |
| Study ends | August 31, 2028 |
| Registry record updated | July 29, 2025 |
| Trial ID | NCT07091877 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are treatment-seeking adults (18–65) with DSM-5 cocaine use disorder who are in early abstinence (<2 months) and are able to complete EEG-based testing and cognitive tasks.
✕Probably not a fit
People with recent positive urine drug screens, uncontrolled or disqualifying psychiatric or neurological disorders, or who cannot undergo EEG (for example due to non-removable hair styles preventing electrode contact) may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This 5-year longitudinal study will enroll 252 treatment-seeking adults (age 18–65) with DSM-5 cocaine use disorder and will track cue-reactivity using EEG and behavioral markers during early abstinence. Approximately 126 participants will be randomly assigned to repeated cognitive reappraisal tasks while the remainder complete a control cue-reactivity task, with repeated visits to measure change over time. The primary endpoints are time-related changes in brain and behavioral indices with cognitive reappraisal during abstinence, and secondary analyses will examine whether those changes relate to clinical outcomes such as craving and relapse. Testing and EEG sessions will be conducted in person at Icahn School of Medicine at Mount Sinai in New York City.
Why it matters
Potential benefit: If successful, cognitive reappraisal could reduce cue-driven cravings and dampen brain responses to cocaine cues, potentially lowering relapse risk.
How similar studies have gone: Prior laboratory and small clinical studies have shown that cognitive reappraisal can reduce cue-elicited craving and alter EEG/fMRI signals in substance use disorders, but large longitudinal randomized evidence specifically in cocaine use disorder is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ability to understand and give informed consent * Age 18-65 * DSM-5 Diagnosis of CUD (Cocaine Use Disorder) * Have appropriate abstinence duration (i.e., \<2 months) at the first visit. * Must be seeking treatment for CUD (at the first visit) Exclusion Criteria: * DSM-5 diagnosis for other psychiatric illnesses (other than mood and anxiety disorders that are highly comorbid with substance use disorders) * Urine positive for any psychoactive drugs (e.g., cocaine, methamphetamine, cannabis, opiates, benzodiazepines, etc.) at baseline * Head trauma with loss of consciousness * History of neurological diseases, including seizures * Thick and/or non-removable hair braids that present difficulty for EEG electrode-scalp contact
Where it's running
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Icahn School of Medicine at Mount Sinai
New York, New York, United States Recruiting
Study contacts
- Principal investigator: Muhammad A Parvaz, PhD — Icahn School of Medicine at Mount Sinai
- Study coordinator: Muhammad A Parvaz, PhD
- Email: muhammad.parvaz@mssm.edu
- Phone: 212-241-3638
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.