GPR52-based probes to help cocaine use disorder
Official title: Discovery of GPR52 ligand probes for cocaine use disorder
Funded at University of Texas Med Br Galveston · NIH-11399734 · Data updated 2026-11-12
A human-focused research effort tests new GPR52-targeting molecules to help people with cocaine use disorder.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | September 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $795,090 |
| NIH project number | 5R01DA060228-02 |
| Project ID | NIH-11399734 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cocaine use disorder may benefit from future therapies developed through this research.
✕Less likely to help
This project focuses on early discovery and may not immediately benefit healthy individuals or those without substance use disorders.
What this research studies
This project uses computer-guided analysis and lab tests to find compounds that interact with the GPR52 receptor, which is involved in brain reward pathways. Researchers will create cell assays to see how these compounds affect signaling in neurons related to cocaine use. If successful, the work could lead to new medicines that lessen cravings and improve recovery for people with cocaine use disorder. The study is designed with clear steps from identifying promising molecules to validating their effects in relevant cellular systems.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that reduce cocaine cravings and support recovery.
How similar studies have gone: Prior research has shown that targeting brain receptors can modify drug-seeking behavior, with ongoing efforts building on these approaches.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Allen, John a — University of Texas Med Br Galveston
- Study coordinator: Allen, John a
Related research
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Oligonucleotide therapy to help cocaine use disorder reach the brain
A new ASO-based approach aims to deliver gene-targeting therapy across the blood–brain barrier to help people with cocaine use disorder.
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Accelerated TMS for Cocaine Use Disorder
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.