Understanding how fat tissue affects daily blood pressure rhythms
Official title: Adipose-derived sPRR controls circadian rhythm of blood pressure through inhibition of renal NCC activity
Funded at Utah State Higher Education System--University of Utah · NIH-11121930 · Data updated 2026-11-12
This research explores how a substance from fat tissue helps control your daily blood pressure patterns, which is important for preventing heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $586,558 |
| NIH project number | 5R01HL160020-04 |
| Project ID | NIH-11121930 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is not directly recruiting patients at this stage, but future clinical applications may benefit individuals with nocturnal hypertension or those at risk for cardiovascular disease.
✕Less likely to help
Patients without blood pressure regulation issues or cardiovascular conditions are unlikely to see direct benefit from this specific research.
What this research studies
Our bodies naturally have daily ups and downs in blood pressure and how much salt the kidneys remove. When these daily rhythms are off, especially with high blood pressure at night, it can increase the risk of heart disease. This project looks at how a specific protein from fat tissue, called sPRR, might help keep these blood pressure rhythms in check. We believe sPRR works by interacting with another receptor in the body to adjust how the kidneys handle salt, which directly impacts blood pressure.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat nocturnal hypertension and other cardiovascular diseases by targeting the body's natural blood pressure rhythms.
How similar studies have gone: While the role of circadian rhythms in blood pressure is known, the specific mechanism involving adipose-derived sPRR and its interaction with AT2R is a novel area of exploration.
Where this research is happening
-
Utah State Higher Education System--University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Yang, Tianxin — Utah State Higher Education System--University of Utah
- Study coordinator: Yang, Tianxin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.