Condition

Sleep Deprivation clinical trials and research

• 24Clinical trials
• 4NIH research projects
• 1New in 30 days
• 6Countries

Newest Sleep Deprivation clinical trials

All recruiting trials (24)

• Sleep and circadian care for ICU patients

  This study tests a multicomponent sleep and circadian rhythm program in adult ICU patients to see if it helps keep daily rhythms and sleep better.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07869901

• HBS-104 single doses in acutely sleep-deprived healthy adults

  This study tests whether a single dose of HBS-104 is safe and how it behaves in the body when given to healthy adults who are acutely sleep-deprived.

  Recruiting Phase 1 Harmony Biosciences Management, Inc. · Eatontown, New Jersey · NCT07848659

• Mind After Midnight — how being awake between 2:00 and 4:00 AM affects mood and decision-making

  This project will test whether being awake during the biological night (2:00–4:00 AM) increases negative mood, poor decision-making, and suicidal thoughts in adults who have had suicidal ideation in the past six months.

  Recruiting University of Arizona · Tucson, Arizona · NCT07438912

• Nighttime synchronization of eating and your circadian clock

  This trial will test whether changing light exposure and when you eat during short sleep periods changes metabolism in healthy adults aged 18–35 who normally sleep 7–9 hours per night.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07329283

• How the body clock affects time perception during 36 hours awake

  This test will see if the internal body clock and staying awake for about 36 hours change how healthy adults experience and estimate time.

  Recruiting University of Aarhus · Aarhus · NCT07294781

• Effects of Sleep Loss and Alcohol on Brain and Performance in Healthy Adults

  This study tests how sleep deprivation and moderate alcohol use affect thinking and motor skills in healthy adults to understand risks that could relate to spaceflight.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07293494

• How 24-hour sleep loss affects people with different APOE genes

  This will see if 24 hours without sleep changes blood Alzheimer's-related markers in healthy adults with different APOE gene types.

  Recruiting Guangdong Provincial Hospital of Traditional Chinese Medicine · Guangzhou, Guangdong · NCT07085754

• Non-invasive craniocervical lymphatic drainage to improve memory and thinking after sleep loss

  This trial will try a gentle, non-invasive craniocervical lymphatic drainage technique to see if it improves memory and thinking in adults who are sleep-deprived.

  Recruiting The George Institute · Tianjin · NCT07084701

• Testing a sleep intervention for expectant and new mothers

  This study is testing a new sleep program for expectant and new mothers to see if it can help them get better sleep during and after pregnancy.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT06737055

• Investigating how night shift work affects women's health during their menstrual cycle

  This study tests how working night shifts and lack of sleep affects the health of young women during different stages of their menstrual cycle.

  Recruiting Uppsala University · Uppsala, Uppsala County · NCT06683248

• Effects of partial sleep deprivation on heart function during cycling

  This study is testing how not getting enough sleep affects heart function and blood pressure during cycling in young healthy adults, while also looking for differences between men and women.

  Recruiting University of Guelph · Guelph, Ontario · NCT06679543

• Impact of 24-hour shifts on immune function in surgery residents

  This study tests how working 24-hour shifts affects the immune system of surgery residents by looking at their blood samples and health data.

  Recruiting University of Chicago · Chicago, Illinois · NCT06636318

• Exploring the effects of sleep loss on aging and cognitive decline

  This study is testing how not getting enough sleep affects thinking and aging in healthy people and those with memory problems or Alzheimer's disease.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT06492109

• Investigating the Role of Naps in Infant Memory Development

  This study is testing how taking naps affects memory development in babies aged 9 to 15 months.

  Recruiting University of Massachusetts, Amherst · Amherst, Massachusetts · NCT06399939

• Increasing sleep duration to improve health in people with obesity

  This study is testing if getting an extra 2 hours of sleep each night can help people with obesity improve their health and insulin sensitivity.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06180837

• Effects of Sleep Deprivation on Itch and Pain Sensitivity

  This study tests how not getting enough sleep affects how much people feel itchiness and pain, and looks at how anxiety and depression might play a role in that.

  Recruiting Aalborg University · Aalborg · NCT06081998

• Improving resilience to sleep deprivation with diet and ketones

  This study is testing if a ketogenic diet or ketone supplements can help healthy adults handle the negative effects of not getting enough sleep.

  Recruiting Ohio State University · Columbus, Ohio · NCT06075914

• Impact of Eating Duration on Cardiovascular Risk in Short Sleepers

  This study is testing if changing the eating hours of people who sleep less than 6.5 hours a night can improve their heart and metabolic health.

  Recruiting Pennington Biomedical Research Center · Baton Rouge, Louisiana · NCT06070194

• Understanding how sleep affects metabolism and weight gain

  This study is testing how not getting enough sleep and the timing of sleep can affect metabolism and weight gain in people.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT05775627

• Personalized caffeine dosing for better performance during sleep deprivation

  This study is testing if a personalized caffeine plan can help people perform better and feel less tired after not getting enough sleep.

  Recruiting at 2 sites University of Arizona · Tucson, Arizona and 1 other locations · NCT05588934

• Improving sleep and circadian alignment in critically ill patients in the ICU

  This study tests a new approach to help critically ill patients in the ICU get better sleep and improve their body clocks by using strategies like light exposure and mobility.

  Recruiting at 2 sites Yale University · New Haven, Connecticut and 1 other locations · NCT05551325

• Monitoring fatigue and attention in sleep-deprived medical residents

  This study is testing a new device that helps track fatigue and alertness in medical residents working night shifts to see if it can spot changes in their brain activity when they’re sleep-deprived.

  Recruiting Assistance Publique - Hôpitaux de Paris · Garches · NCT05531734

• Investigating how sleep loss affects emotion regulation

  This study is testing how losing sleep for three nights affects people's ability to handle their emotions compared to those with insomnia and healthy individuals.

  Recruiting Beth Israel Deaconess Medical Center · Boston, Massachusetts · NCT05393830

• Slow-wave (SO) electrical brain stimulation during deep (NREM) sleep

  This trial tests whether a short, gentle electrical stimulation to the scalp during deep sleep can boost slow-wave activity and help healthy adults stay alert and perform better after sleep deprivation.

  Recruiting U.S. Army Medical Research and Development Command · Bethesda, Maryland · NCT02945501

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding the link between sleep and binge drinking in college students

  This project looks at how sleep and binge drinking affect each other in college students to better understand the risks of alcohol misuse.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-11098635

• Exploring how lack of sleep affects gut health

  This study is looking at how not getting enough sleep can affect gut health, using fruit flies to help us understand how sleep loss might change the gut and increase the risk of heart and metabolic issues.

  NIH research Harvard Medical School · Boston, United States · NIH-11062506

• How sleep deprivation affects thinking and mood

  This study looks at how not getting enough sleep can affect thinking and increase the chances of feeling depressed, using animal models to learn more about what happens in the brain when we don’t sleep well, with hopes of finding new ways to help people who struggle with mood issues related to sleep loss.

  NIH research University of Utah · Salt Lake City, United States · NIH-10886925

• Understanding how lack of sleep affects decision-making in the brain.

  This study looks at how not getting enough sleep affects our ability to make decisions when things change, using mice and rats to explore what happens in their brains when they're sleep-deprived, so we can learn more about why we might struggle to adapt when we're tired.

  NIH research Washington State University · Pullman, United States · NIH-10791860

Related topics

Quick answers

How many Sleep Deprivation clinical trials are recruiting right now?

24, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (15 trials), China (4 trials), Denmark (2 trials), Sweden (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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