Understanding sleep issues in cystic fibrosis patients
Official title: Altered Circadian Rhythm Regulation in Cystic Fibrosis
Funded at Case Western Reserve University · NIH-11060056 · Data updated 2026-11-12
This study is looking at how changes in sleep patterns affect the sleep quality of children and young adults with cystic fibrosis, and it hopes to find ways to help improve their sleep and health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | April 15, 2022 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $563,589 |
| NIH project number | 5R01HL156928-04 |
| Project ID | NIH-11060056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with cystic fibrosis who experience sleep disturbances.
✕Less likely to help
Patients without cystic fibrosis or those who do not experience sleep issues may not benefit from this research.
What this research studies
This research investigates how circadian rhythm disruptions affect sleep quality in children and young adults with cystic fibrosis (CF). It explores the relationship between altered sleep patterns and the severity of CF symptoms, including respiratory and digestive issues. The study utilizes advanced techniques to measure sleep disturbances and aims to determine the underlying biological mechanisms, such as microtubule instability and melatonin production, that contribute to these issues. By understanding these connections, the research seeks to identify potential therapeutic approaches to improve sleep and overall health in CF patients.
Why it matters
Potential benefit: If successful, this research could lead to improved sleep quality and better health outcomes for patients with cystic fibrosis.
How similar studies have gone: Previous research has indicated that addressing circadian rhythm disruptions can lead to improved health outcomes in other patient populations, suggesting potential for success in this area as well.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Kelley, Thomas J — Case Western Reserve University
- Study coordinator: Kelley, Thomas J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.