Sleep, mood, and mouth bacteria in teens and young adults
Official title: Sleep and Circadian Rhythm Phenotypes in Adolescent Depression: Exploring the Role of the Oral Microbiome
Funded at Emma Pendleton Bradley Hospital · NIH-11336433 · Data updated 2026-11-12
A teen/young adult study will look at how sleep patterns and circadian rhythms relate to the bacteria in the mouth and to depression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emma Pendleton Bradley Hospital NIH-funded |
| Lab location | 1 site (Riverside, UNITED STATES) |
| Project start | April 6, 2021 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $185,106 |
| NIH project number | 2P20GM139743-06 |
| Project ID | NIH-11336433 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adolescents and young adults, including those with depression and related sleep issues, who can provide data or samples.
✕Less likely to help
Individuals without depression or sleep disturbances may have less direct benefit from the study results.
What this research studies
This project will examine how sleep timing and daily rhythms may shape the oral microbiome in adolescents and young adults who experience depression. Using data from a national survey, researchers will analyze relationships between microbiome makeup, sleep/wake patterns, and mood symptoms. The goal is to understand whether circadian misalignment could influence oral health and mental well-being in this age group. The study builds on prior observations and will replicate findings in a larger, representative population of youths and young adults.
Why it matters
Potential benefit: If successful, findings could inform interventions that improve both oral health and mood by aligning sleep and daily routines.
How similar studies have gone: Prior adult studies suggest a link between depression and oral microbiome differences, but replication in younger populations is needed.
Where this research is happening
-
Emma Pendleton Bradley Hospital
Riverside, United States Active
Researchers
- Principal investigator: Narcisse, Marie-Rachelle — Emma Pendleton Bradley Hospital
- Study coordinator: Narcisse, Marie-Rachelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.