How the body's internal clock affects stress responses and heart health
Official title: Role of the circadian rhythm on endocannabinoid response to an acute stress
Funded at Oregon Health & Science University · NIH-11005761 · Data updated 2026-11-12
This study looks at how our body's internal clock affects the way we respond to stress and how it might impact heart health, especially for people who work night shifts or have unusual schedules.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $173,184 |
| NIH project number | 5K01HL151745-05 |
| Project ID | NIH-11005761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 who experience acute stress, particularly those who work night or rotating shifts.
✕Less likely to help
Patients who do not experience acute stress or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how the body's circadian rhythm influences the response of endocannabinoids, which are natural compounds that help regulate stress and cardiovascular function, during acute stress events. The study will examine how these responses vary depending on the time of day and how they relate to emotional and cardiovascular reactions. By understanding these mechanisms, the research aims to shed light on the risks of cardiovascular disease, particularly in individuals who work night shifts or have irregular schedules.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing stress and reducing cardiovascular risks, especially for shift workers.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in stress responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Bowles, Nicole P — Oregon Health & Science University
- Study coordinator: Bowles, Nicole P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.