Sleep and body‑clock patterns during opioid treatment
Sleep and circadian rhythm phenotypes and mechanisms associated with opioid use disorder treatment outcomes
This project follows people on buprenorphine or methadone to see how sleep and daily body‑clock patterns relate to returning to opioid use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11171667 on NIH RePORTER |
What this research studies
If you are receiving buprenorphine or methadone for opioid use disorder, researchers will follow you for six months while you remain in treatment. They will collect sleep information (including sleep duration, sleep architecture, and breathing during sleep), measures that reflect daily circadian rhythms, and reports or tests about opioid use. The team will also track mood (positive and negative affect) to explore how feelings may link sleep patterns with return to nonmedical opioid use. Data are gathered through collaborations with community treatment providers and repeated measurements over time to look for patterns that predict outcomes.
Who could benefit from this research
Good fit: Adults enrolled in buprenorphine or methadone treatment for opioid use disorder who can participate in serial sleep and mood measurements over six months are ideal candidates.
Not a fit: People not currently in MOUD (buprenorphine or methadone) treatment or those unwilling/unable to complete sleep monitoring and follow‑up likely would not benefit directly from participating.
Why it matters
Potential benefit: If successful, this work could point to sleep‑ or rhythm‑focused approaches that help reduce return to opioid use among people on medication for OUD.
How similar studies have performed: Previous research links opioid use to sleep problems, but longitudinal studies tying objective sleep and circadian measures to return to opioid use during treatment are limited, making this partly novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Huhn, Andrew S — Johns Hopkins University
- Study coordinator: Huhn, Andrew S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.