How HIV and liver diseases affect body clock rhythms
Official title: Impact of HIV co-infections and comorbidities on circadian rhythm in the liver
Funded at Emory University · NIH-11163530 · Data updated 2026-11-12
This study is looking at how having HIV and liver diseases can mess with your body's natural sleep and wake cycles, and it's for people living with HIV who want to understand how these issues might affect their health and what new treatments could help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $548,914 |
| NIH project number | 5DP1DK139804-02 |
| Project ID | NIH-11163530 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals living with HIV who also have chronic hepatitis B or non-alcoholic fatty liver disease.
✕Less likely to help
Patients without HIV or those who do not have any liver-related diseases may not benefit from this research.
What this research studies
This research investigates how HIV co-infections and related liver diseases, such as chronic hepatitis B and non-alcoholic fatty liver disease, disrupt the body's circadian rhythms. By using advanced cell culture techniques and in vivo systems, the study aims to understand the biological processes that occur in the liver of individuals living with HIV. The goal is to uncover how these disruptions may lead to complications and to explore potential new treatments that could improve health outcomes for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals living with HIV and related liver diseases by addressing the impact of circadian rhythm disruptions.
How similar studies have gone: While the specific combination of HIV, liver diseases, and circadian rhythms is relatively novel, there is existing research indicating that understanding these interactions can lead to significant advancements in treatment.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Michailidis, Eleftherios — Emory University
- Study coordinator: Michailidis, Eleftherios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.