How disruptions in sleep patterns affect blood vessel responses in Alzheimer's disease
The effect of circadian rhythm disruptions on the angiogenic response to hypoperfusion in the AD brain
This study is looking at how changes in your body's natural clock might affect blood flow and the growth of new blood vessels in the brains of people with Alzheimer's, to better understand how these factors influence thinking and memory.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11015819 on NIH RePORTER |
What this research studies
This research investigates the relationship between circadian rhythm disruptions and the body's ability to form new blood vessels in the brains of Alzheimer's disease patients. It aims to understand how insufficient blood flow affects cognitive function and how the normal processes of blood vessel growth are altered in Alzheimer's. By examining the brain's vascular responses to low blood flow, the study seeks to uncover the mechanisms that contribute to the progression of Alzheimer's disease. The research utilizes advanced imaging techniques to analyze changes in brain cells and blood vessels over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease who may also experience disruptions in their sleep patterns.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance blood flow and improve cognitive function in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of vascular health in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Arai, Ken — Massachusetts General Hospital
- Study coordinator: Arai, Ken
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.