Lineage Addiction in Prostate Cancer: Molecular Interactions and Biomarker Clues
Official title: Lineage Addiction in Prostate Cancer: Molecular Interactions and Translational Biomarkers
Funded at University of Wisconsin-Madison · NIH-11389350 · Data updated 2026-11-12
This grant explores how advanced prostate cancer that no longer fully responds to standard therapy might be driven by specific molecular changes and biomarkers, aiming to inform better treatment sequencing for American men.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | August 11, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $636,167 |
| NIH project number | 5P01CA298991-02 |
| Project ID | NIH-11389350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Men with metastatic, castration-resistant prostate cancer and evidence of AR pathway dependence or related molecular alterations.
✕Less likely to help
Patients without AR pathway alterations or without progression on AR-targeted therapies may see limited direct benefit.
What this research studies
Researchers at University of Wisconsin–Madison will study how different molecular pathways interact in metastatic prostate cancer that persists despite AR-targeted therapies. Using large-scale genomic and transcriptomic data from metastatic biopsies, the project seeks to identify key drivers and biomarkers that indicate which patients may benefit from particular treatment sequences or new interventions. The work aims to translate these molecular findings into clinical signals that help doctors personalize therapy for men with castration-resistant disease. The grant focuses on understanding AR-dependent and AR-independent tumor states to guide future therapies.
Why it matters
Potential benefit: Understanding molecular drivers could lead to more precise, personalized treatment plans for men with advanced prostate cancer.
How similar studies have gone: Previous analyses have shown that integrating genomic data can reveal actionable biomarkers in CRPC, suggesting this approach could yield translatable findings.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Lang, Joshua — University of Wisconsin-Madison
- Study coordinator: Lang, Joshua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.