Center for Systems Neurogenetics of Addiction (CSNA)
Official title: Center for Systems Neurogenetics of Addiction
Funded at Jackson Laboratory · NIH-11389620 · Data updated 2026-11-12
A research center is studying how genetic and brain factors influence cocaine addiction, using mouse models and human genetics to understand why some people are more prone to drug seeking.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | August 15, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $2,419,183 |
| NIH project number | 5P50DA039841-10 |
| Project ID | NIH-11389620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with cocaine use disorder or those at risk due to genetic/biological factors may benefit from future translational findings.
✕Less likely to help
Patients without cocaine use disorder or related risk factors may not directly benefit from this basic science work.
What this research studies
This center brings together behavioral neuroscience, computational science, genome biology, and genetics in both mice and humans to map biological processes that affect cocaine use and addiction. Researchers use specialized mouse populations and advanced phenotyping to link genetic variation with different addiction-related behaviors, such as impulsivity and self-administration. The work aims to uncover shared and unique biological mechanisms that drive risk for addiction, with a focus on how genetics interacts with behavior and environment. The findings could help identify targets for prevention and treatment in people affected by cocaine use disorder.
Why it matters
Potential benefit: Could lead to new strategies for prevention and personalized treatment of cocaine addiction based on genetic and neurobiological factors.
How similar studies have gone: Past studies using animal genetics and neurobiology have yielded insights into addiction mechanisms, supporting the potential for translational impact.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Chesler, Elissa J — Jackson Laboratory
- Study coordinator: Chesler, Elissa J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.