Comparative evaluation of nicotine analogs for nicotine EC users
Official title: Comparative Evaluation of Nicotine Analogs
Run by Ohio State University Comprehensive Cancer Center · NCT07585006 · Data updated 2026-11-12
This early-stage trial tests whether two nicotine-like compounds (6-MN and nicotinamide) differ from nicotine in how they feel, how much people use them, and how they affect the body in adult e-cigarette users.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Ohio State University Comprehensive Cancer Center Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Status | Recruiting |
| Started | May 29, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT07585006 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 21+ who are current regular e-cigarette users (at least 3 months) and willing to abstain from nicotine/tobacco/marijuana for 12+ hours before visits.
✕Probably not a fit
Participants who do not experience similar subjective effects or who do not show differing demand between analogs and nicotine may not derive direct personal benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 1 study enrolls adults who regularly use electronic cigarettes to compare nicotine analogs with nicotine. Participants go through multiple visits in which they sample an e-cigarette containing nicotine, 6-MN, or nicotinamide, then can use the product freely for a period, allowing researchers to measure subjective effects, demand, puffing behavior, and basic pharmacokinetics. Cardiovascular effects are monitored to assess acute safety. The study uses randomized sequences to reduce bias and collects biological samples and behavioral data. The goal is to understand addictiveness and usage patterns of nicotine analogs relative to nicotine.
Why it matters
Potential benefit: If successful, the study could clarify whether nicotine analogs produce similar reinforcing effects and inform future regulation or product design to reduce addiction risk.
How similar studies have gone: Prior work in nicotine products has shown measurable differences in reinforcing effects across nicotine-containing products, but data on nicotine analogs are limited and this approach is relatively exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 21 years or older * Current adult EC user for at least the past 3 months (confirmed by cotinine testing strip) * Willing and able to provide informed consent * Willing to abstain from using any nicotine, tobacco, or marijuana products for 12 or more hours prior to the three lab visits * Able to read, write, and speak English Exclusion Criteria: * Currently attempting to quit nicotine or tobacco products * Use of other tobacco or nicotine products \> 10 days in the past month * Have had a recent cardiac event or distress (defined as occurring within the previous 3 months) * Have had a recent serious lung disease or infection (e.g., tuberculosis, cystic fibrosis, asthma, or lung cancer) (defined as occurring in the previous 30 days) * Currently pregnant, planning to become pregnant, or breastfeeding (verified with urine pregnancy test)
Where it's running
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States Recruiting
Study contacts
- Principal investigator: Theodore L Wagener, PhD — Ohio State University Comprehensive Cancer Center
- Study coordinator: The Ohio State University Comprehensive Cancer Center
- Email: OSUCCCClinicaltrials@osumc.edu
- Phone: 800-293-5066
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.