Craving and addiction severity: how craving links to changing levels of addiction in daily life
Official title: Symptom Networks Characteristics and Centrality of Craving as Markers of Transition Across Levels of Addiction Severity: A Longitudinal Study
Run by University of Bordeaux · NCT07734363 · Data updated 2026-11-12
This observational study tests whether craving and the way different addiction symptoms interact can predict changes in addiction severity over two years for adults with substance use disorders.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | University of Bordeaux Academic / other |
| Locations | 1 site (Bordeaux) |
| Status | Recruiting |
| Started | May 20, 2026 |
| Main results expected | December 2030 |
| Study ends | June 2031 |
| Registry record updated | July 29, 2026 |
| Trial ID | NCT07734363 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults who identify a primary substance with regular use (at least twice weekly) and a current DSM-5 SUD diagnosis.
✕Probably not a fit
Individuals without a primary substance use disorder or those unable to comply with smartphone-based data collection may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This longitudinal observational study follows adults with a primary substance use disorder to see how craving relates to other symptoms over time. Researchers will collect daily life data using ecological momentary assessment and perform annual DSM-5 evaluations, focusing on symptom networks, centrality of craving, and how these relate to severity trajectories. They will also examine a wide range of demographic, cognitive, psychological, and quality-of-life factors to identify predictors of progression. Analyses will include correlations and regression models at baseline, 1-year, and 2-year follow-ups in order to characterize trajectories of addiction severity.
Why it matters
Potential benefit: If successful, findings could help identify early markers of worsening severity and inform personalized monitoring or intervention strategies.
How similar studies have gone: Similar approaches using symptom networks and craving have shown promise in understanding addiction dynamics, but this exact longitudinal network analysis is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria * Be over 18 years of age * Identify a primary substance as a main problematic substance use. * Be a regular user (at least twice a week in the last 30 days) of a primary substance (defined as their main problematic substance use). * Present a current diagnosis of SUD for this primary substance according to DSM-5 criteria. Exclusion Criteria * Medical, psychiatric or addiction condition that warrants immediate inpatient treatment intervention. * Somatic, cognitive or other disorders preventing the use of the smartphone device (deafness, impaired vision, illiteracy….). * Not being familiar with the use of smartphone * Having a smartphone not compatible with the application and being unable to visit the laboratory to receive a loaner phone for the study. * Difficulty in understanding and/or writing and/or reading French. * Individuals participating in another study that includes an ongoing exclusion period. * Be deprived of liberty due to an ongoing legal procedure. * Be under legal protection. * Be under guardianship or conservatorship.
Where it's running
-
Université de Bordeaux CNRS UMR 6033 SANPSY
Bordeaux, France Recruiting
Study contacts
- Principal investigator: Fuschia SERRE — University of Bordeaux
- Study coordinator: Fuschia SERRE, Ph-D
- Email: fuschia.serre@u-bordeaux.fr
- Phone: +33 05 56 56 17 38
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.