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Clinical trials and research at University of Virginia

• 93Clinical trials
• 896NIH research projects
• 4Countries

Newest trials

All recruiting trials (93)

• Cardiorespiratory and muscular fitness in children with obesity and autism

  This study tests whether cardiorespiratory fitness and handgrip strength differ between children with obesity who have autism and those who do not, and how these fitness measures relate to body size, composition, and cardiometabolic health.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07804680

• Obesity's effect on muscle insulin action and cardiorespiratory fitness in type 1 diabetes

  This will see if muscle insulin resistance and excess weight are linked to lower cardio fitness in adults with type 1 diabetes compared with healthy controls before and after a high-intensity interval training program.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07573228

• CARRII Native Intervention Optimization: Finding the Best Online Help for Native Women at Risk of Alcohol-Exposed Pregnancy

  This trial tests different online components of CARRII to see which mix best reduces risk of alcohol-exposed pregnancy among Native women who could become pregnant and drink.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07547696

• Use of a smartwatch to track hot flashes in men receiving androgen deprivation therapy

  This project will try using a smartwatch to record hot flashes and other health signals in men with prostate cancer on androgen deprivation therapy and compare those records with daily survey reports.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07535541

• HER2 FPBMC therapy for metastatic breast and prostate cancer

  This study tests whether infusing patients with their own immune cells, armed with a HER2-targeting antibody, can help treat metastatic breast or prostate cancer.

  Recruiting Phase 1/2 University of Virginia · Charlottesville, Virginia · NCT07441889

• MRI-guided focused ultrasound mesencephalotomy for opioid-resistant head, neck, and brachial cancer pain

  This study will try MRI-guided focused ultrasound to make a tiny, precise lesion in the midbrain to relieve severe, opioid-resistant head, neck, or brachial cancer pain.

  Recruiting University of Virginia · Boston, Massachusetts and 5 other locations · NCT07405645

• Low‑intensity focused ultrasound with EGFR‑targeted T‑cell therapy for newly diagnosed unmethylated glioblastoma

  This trial is testing whether opening the blood–brain barrier with low‑intensity focused ultrasound can help autologous EGFR‑bispecific antibody‑armed T cells reach and treat newly diagnosed MGMT‑unmethylated, IDH‑wildtype glioblastoma.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT07343986

• Boosting resilience and reducing chronic low back pain by treating sleep and adding meditation or pain education

  This program tests whether adding savoring meditation or extra pain education to a cognitive behavioral sleep program helps adults with chronic low back pain and insomnia have less pain.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07298941

• Different weekly feedback messages to support weight loss

  This project will test whether different weekly feedback messages delivered via a smartphone app help adults with overweight or obesity lose weight.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07292389

• CD33-armed immune cell treatment for adults with MRD-positive AML or MDS

  This treatment will try giving adults with MRD-positive AML or MDS infusions of their own T cells coated with a CD33-directed bispecific antibody together with standard hypomethylating therapy (and possibly venetoclax) to see if it is safe and lowers residual disease.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT07270978

• Improving nasal-sounding speech and swallowing in head and neck cancer survivors with velopharyngeal dysfunction

  This pilot effort tests whether injecting material to 'plump' the back wall of the throat (pharyngeal wall augmentation) can help head and neck cancer survivors with velopharyngeal dysfunction speak less nasally and swallow better.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07264036

• A new insulin-sensitizing pill for adults with type 1 diabetes using closed‑loop insulin delivery

  This 12-week test will see if the oral drug CIR-0602K helps adults with type 1 diabetes who use closed-loop insulin systems spend more time in their target glucose range and use less insulin.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07186660

• Home test to predict postpartum depression

  This project will test whether the Enlighten blood or saliva test taken in late pregnancy can predict which pregnant women (age 18+, singleton pregnancies enrolled before 30 weeks) will develop postpartum depression in the first three months after birth.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07186309

• High-intensity interval training and causes of low cardiorespiratory fitness in people with ANOCA

  This project will test whether a four-week remotely monitored high-intensity interval training (HIIT) program can safely improve fitness, heart function, and quality of life for adults with angina but no obstructive coronary artery disease (ANOCA).

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07182955

• Measuring the fat around the heart in people with HFpEF

  This research will test a new free-breathing 3D cardiac MRI to measure epicardial fat composition and see if those measurements link to symptoms or help guide treatment for people with HFpEF.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT07178145

• Lower local anesthetic concentration and rebound shoulder pain after shoulder arthroplasty

  This study tests whether using a lower concentration of local anesthetic in a nerve block reduces rebound pain 24 hours after shoulder replacement surgery.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT07146685

• Beetroot juice to boost blood vessels, insulin sensitivity, and exercise in prediabetes on vs. off metformin

  In people with prediabetes, this study tests whether short-term inorganic nitrate from beetroot juice can improve blood vessel health, insulin sensitivity, and exercise capacity, and compares those already taking metformin with those who are not.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT07131384

• BCG vaccine to treat MAC lung disease

  This will test whether a single BCG vaccine injection can safely boost immunity and help adults with Mycobacterium avium complex (MAC) lung disease.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07094711

• HCMR Re-Imaging for Hypertrophic Cardiomyopathy Follow-up

  We will do follow-up heart MRI scans to see if gadolinium scarring (LGE) predicts future dangerous heart rhythms or heart failure in adults who were in the original HCMR cohort and have hypertrophic cardiomyopathy.

  Recruiting at 3 sites University of Virginia · Boston, Massachusetts and 7 other locations · NCT07054073

• Hyperpolarized xenon-129 MRI signatures to detect and manage acute cellular rejection after lung transplant

  We will see if hyperpolarized xenon-129 MRI can detect early acute cellular rejection in recent lung transplant recipients and guide targeted bronchoscopic sampling.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT07046910

• weSIPsmarter: a digital program to reduce sugary drinks among rural Head Start preschoolers and their parents

  This program will test whether weSIPsmarter, a parent-focused digital program, helps preschoolers and their parents in rural Head Start programs drink fewer sugary beverages.

  Recruiting University of Virginia · Christiansburg, Virginia · NCT07046351

• Which form of estrogen best improves bone strength in women with functional hypothalamic amenorrhea?

  This trial will test whether natural estrogen patches, natural estrogen pills, or a birth-control estrogen patch better improve bone strength over one year in adolescents and young women with functional hypothalamic amenorrhea.

  Recruiting at 2 sites Phase 2 University of Virginia · Charlottesville, Virginia and 1 other locations · NCT07010146

• Improving TB screening in rural, undernourished communities

  This project will test whether giving conditional cash transfers to households of people starting drug-sensitive pulmonary TB in rural Tanzania increases screening of household contacts and measures how undernutrition affects progression to active TB.

  Recruiting University of Virginia · Haydom, Manyara Region · NCT06971952

• Nitrate Beetroot Juice to Help Blood Flow in Women with ANOCA and CMD

  We’re testing whether nitrate-rich beetroot juice for 14 days can improve heart blood flow and quality of life for women with ANOCA and CMD compared with a placebo.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06948201

• Ketamine added to levetiracetam to stop prolonged convulsive seizures

  This trial will test whether giving ketamine (two different doses) along with levetiracetam helps stop benzodiazepine-refractory status epilepticus in people age 1 and older.

  Recruiting at 36 sites Phase 3 University of Virginia · Birmingham, Alabama and 62 other locations · NCT06907173

• Bone health in 12–21-year-olds starting GLP-1 weight medicines

  This study will test whether starting GLP-1 receptor agonist medicines versus lifestyle management changes bone health over 24 months in 12–21-year-olds with obesity.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT06903923

• Increasing lean protein intake in preschoolers to assess effects on cognition and health

  This study tests if adding more lean protein to preschoolers' meals can help them feel full, think better, and improve their health.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06882252

• Comparing early and delayed rehabilitation after shoulder surgery for fractures

  This study is testing whether starting physical therapy two weeks or six weeks after shoulder surgery helps patients recover better from their fractures.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06869343

• Using MRI to Measure Lung Damage in Young E-cigarette Users

  This study is trying to see how using e-cigarettes affects lung health and fitness in young people by comparing them to those who don’t use e-cigarettes over a year.

  Recruiting at 2 sites Phase 2/3 University of Virginia · Durham, North Carolina and 1 other locations · NCT06856525

• Hyperpolarized xenon‑129 MRI for imaging lung function in idiopathic pulmonary fibrosis

  This will test whether inhaling hyperpolarized xenon‑129 during MRI can safely show lung ventilation and perfusion changes over time in people with idiopathic pulmonary fibrosis.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06853145

• Blood test to predict postpartum depression in pregnant women

  This study is testing a blood test to see if it can predict postpartum depression in pregnant women during their third trimester.

  Recruiting at 2 sites University of Virginia · Charlottesville, Virginia and 1 other locations · NCT06831968

• Comparing IV methadone versus IV remifentanil for pain and recovery after craniotomy

  This trial will test whether a single dose of IV methadone given during surgery provides better pain control and recovery than IV remifentanil for adults having supratentorial craniotomy.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06810336

• Monitoring oxygen therapy usage in COPD patients

  This study is testing a new device that tracks how well COPD patients are using their oxygen therapy to help them breathe better and stay healthier.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06810323

• Comparing insulin treatment with or without metformin for gestational diabetes

  This study is testing if pregnant women with gestational diabetes can benefit from continuing metformin along with insulin to see if it helps them and their babies stay healthier.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT06781775

• Psilocybin to help people with prolonged grief disorder

  This study will test whether a single 25 mg dose of psilocybin can reduce grief and trauma symptoms in adults with prolonged grief disorder.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06724289

• Expanding access to epilepsy care in western Kenya (BEACON)

  This project will see if training local health workers to use an epilepsy medical-records and patient-tracking system helps people aged 12 and older in western Kenya stay on antiseizure medicines and remain in care.

  Recruiting University of Virginia · Eldoret · NCT06623994

• TodaysBaby mobile safe-sleep support for new parents

  This program tests the TodaysBaby mobile safe-sleep messaging for parents of healthy, full-term newborns to see if it improves safe sleep practices and reaches families equally across income and race/ethnicity.

  Recruiting University of Virginia · Boston, Massachusetts · NCT06618586

• Improving heart blood flow and angina in women using an SGLT2 pill (STRONG)

  This trial will test whether taking the SGLT2 pill Brezavvy for 12 weeks can improve coronary microvascular blood flow and reduce angina symptoms in women with non-obstructive coronary artery disease.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06600178

• Understanding kidney disease in people with cystic fibrosis

  This study looks at how cystic fibrosis affects kidney health by checking blood and urine samples to help find ways to spot and prevent kidney problems early.

  Recruiting at 3 sites University of Virginia · Birmingham, Alabama and 2 other locations · NCT06595420

• Pre-operative endocrine therapy for older women with early-stage breast cancer

  This study is testing if giving older women with early-stage breast cancer a 90-day treatment before surgery can help them tolerate the treatment better and decide if they need radiation afterwards.

  Recruiting at 6 sites Phase 3 University of Virginia · New Haven, Connecticut and 5 other locations · NCT06507618

• Beetroot nitrate plus exercise intensity for heart and fitness in postmenopausal women

  This project will test whether adding inorganic nitrate (beetroot juice) to moderate or high-intensity exercise improves vascular health and fitness in sedentary postmenopausal women.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06480695

• Treatment for advanced pancreatic cancer using engineered immune cells

  This study is testing a new treatment that uses specially modified immune cells to see if it can help people with advanced pancreatic cancer feel better and fight their disease.

  Recruiting Phase 1/2 University of Virginia · Charlottesville, Virginia · NCT06479239

• Using focused ultrasound and an immune-activating drug for advanced melanoma treatment

  This study is testing a new treatment that combines focused ultrasound and an immune-boosting drug to see if it can help adults with advanced melanoma before their surgery.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT06472661

• Home-based exercise programs for men with metastatic prostate cancer

  This study is testing two different home exercise programs to see if they can help men with metastatic prostate cancer feel better while starting their treatment.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06429813

• Using CT scans and biomarkers to improve treatment for pulmonary fibrosis

  This study is testing if special CT scans and biomarkers can help doctors better understand how severe idiopathic pulmonary fibrosis is and how well treatments are working for patients.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06323876

• Text messaging strategies to reduce binge drinking in military personnel

  This study is testing if sending text messages can help young Air Force trainees drink less and avoid problems related to binge drinking.

  Recruiting University of Virginia · San Antonio, Texas · NCT06318975

• Personalized rifampin dosing guided by a urine test

  This trial will test whether a simple urine spectrophotometry test can identify adults and children with low rifampin levels so clinicians can increase doses to reach target blood exposure during treatment for drug‑sensitive pulmonary TB.

  Recruiting Phase 1 University of Virginia · Haydom · NCT06318416

• Using a genetic test to guide blood thinner prescriptions after a stroke

  This study is testing whether a quick genetic test can help doctors choose the right blood thinners for patients who have had a stroke or mini-stroke.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06292117

• Using colchicine to treat acutely decompensated heart failure with reduced ejection fraction

  This study is testing if colchicine, an anti-inflammatory medication, can help people in the hospital with heart failure feel better and improve their heart function.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT06286423

• Using magnesium and riboflavin to treat headaches after a concussion

  This study tests if taking magnesium and riboflavin supplements can help people with concussions feel better by reducing headache pain and how long the headaches last.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT06260072

• Effects of Exercise on Pain and Recovery After Concussion in College Athletes

  This study is testing if different levels of aerobic exercise can help college athletes recover from concussions faster and feel better emotionally.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06246669

• Using recombinant von Willebrand Factor to treat bleeding in ECMO patients

  This study is testing if a new treatment using recombinant von Willebrand Factor can help adults on ECMO who are having serious bleeding problems.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06118372

• Using a chatbot or genetic counselor for cancer genetic screening in rural areas

  This study is testing whether a chatbot or a genetic counselor is better at helping people in rural areas understand cancer genetic screening and decide to get tested for gene mutations.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06089421

• Evaluating vulvovaginitis effects on surgical outcomes after vulvar excision

  This study is testing how common vulvovaginitis is in women having surgery for non-cancerous vulvar conditions and whether it affects their recovery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06070454

• Improving mental health support in middle schools

  This study tests whether different training methods for school staff can help them better support the mental health needs of middle school students.

  Recruiting at 3 sites University of Virginia · Columbia, Missouri and 2 other locations · NCT06047041

• Using sonodynamic therapy for recurrent glioblastoma

  This study is testing a new treatment that uses sound waves and a special drug to see if it can safely help people with recurrent glioblastoma by destroying tumor cells while protecting healthy brain tissue.

  Recruiting Phase 1 University of Virginia · Charlottesville, Virginia · NCT06039709

• Improving pain management for knee surgery patients

  This study is testing if a new way of managing pain that combines savoring meditation with education about pain can help people with knee osteoarthritis feel better after knee surgery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06038240

• Effect of mavacamten on heart blood flow in obstructive hypertrophic cardiomyopathy

  This study is testing if the medication mavacamten can improve blood flow in the hearts of people with obstructive hypertrophic cardiomyopathy after a year of treatment.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06023186

• Exploring the links between oral bacteria, muscle blood flow, and fitness levels

  This study is trying to see how oral bacteria and fitness levels affect blood flow to muscles in people.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT06009276

• Lower dose radiation therapy for HPV positive head and neck cancer

  This study is testing if a lower dose of radiation therapy can safely treat HPV positive head and neck cancer while causing fewer side effects.

  Recruiting at 3 sites Phase 2 University of Virginia · Miami, Florida and 4 other locations · NCT05962242

• Removing cancerous lymph nodes to prevent melanoma recurrence

  This study tests if removing only cancerous lymph nodes can help people with metastatic melanoma avoid cancer coming back and looks at how this surgery affects their quality of life.

  Recruiting at 5 sites University of Virginia · Atlanta, Georgia and 6 other locations · NCT05839912

• Mindfulness and exercise program for bladder cancer surgery patients

  This study is testing a home program that combines exercise and mindfulness to help bladder cancer patients feel better and prepare for their surgery.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05790850

• Using online social networks to promote safe infant care practices

  This study is trying to see if private Facebook groups can help pregnant women and new parents follow safe sleep guidelines and improve breastfeeding by providing them with helpful information and support from others.

  Recruiting University of Virginia · Boston, Massachusetts · NCT05767658

• Reducing blood sugar spikes in early type 2 diabetes through lifestyle changes

  This study is testing if a program that includes tracking blood sugar and personalized lifestyle changes can help people with newly diagnosed type 2 diabetes manage their condition better than standard care.

  Recruiting at 2 sites University of Virginia · Aurora, Colorado and 1 other locations · NCT05766735

• Using ultrasound therapy to treat severe leg ulcers from poor blood flow

  This study is testing if using ultrasound therapy can help heal severe leg ulcers in people with poor blood flow caused by peripheral arterial disease.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05749250

• Investigating melatonin's effects on sleep for resident trainees during night shifts

  This study is testing if melatonin can help resident trainees get better sleep while working night shifts.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT05701969

• Pulsed ultrasound to reduce inflammation by targeting the splenic or cervical vagus nerve

  This study will try pulsed ultrasound on the spleen or neck vagus nerve in healthy adults aged 25–50 to see if it triggers an anti-inflammatory immune response.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05685108

• Using community pharmacists to help rural smokers quit

  This study is testing a new program where pharmacists help rural smokers in Appalachia quit smoking by providing medication and support, like texting and quitline resources.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05660525

• Using artificial pancreas technology to improve heart health in type 1 diabetes

  This study tests if using artificial pancreas technology can help people with type 1 diabetes improve their heart health by better controlling their blood sugar levels.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05653518

• New exercise program for older patients with heart failure

  This study is testing a new exercise program for older patients with heart failure to see if it helps them feel better compared to a standard exercise program.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05609097

• Internet-based therapy for insomnia and cognitive health

  This study is testing whether an online therapy for insomnia can help improve sleep and thinking skills in people with mild cognitive impairment.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT05565833

• Using semaglutide to prevent weight gain after liver transplant

  This study is testing if the medication semaglutide can help people who have had a liver transplant avoid gaining weight and developing liver problems.

  Recruiting Phase 2 University of Virginia · Richmond, Virginia · NCT05424003

• Neuromodulation of the insula to treat chronic neuropathic pain

  This study is testing if stimulating a specific part of the brain can help people with long-lasting nerve pain feel better.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05404581

• Combining chemotherapy and radiation for high-risk breast cancer patients

  This study tests whether combining chemotherapy and radiation can help high-risk breast cancer patients who still have cancer after initial treatment, while also looking at how this treatment affects their immune system.

  Recruiting Phase 2/3 University of Virginia · Charlottesville, Virginia · NCT05288777

• Simplified rehabilitation for ankle and pilon fractures

  This study tests if a simple wooden block stretching routine can help people recover from ankle and pilon fractures just as well as regular physical therapy.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05280639

• Blocking Interleukin-4Ra with Dupilumab to Reduce Staphylococcus in Nasal Polyps

  This study is testing if a medication called dupilumab can help people with nasal polyps reduce harmful bacteria and improve their overall nasal health.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT05094570

• Protecting the heart during treatment for acute myeloid leukemia

  This study is testing if giving heart-protecting medications to people with acute myeloid leukemia who are being treated with daunorubicin can help prevent heart damage during their treatment.

  Recruiting Phase 2 University of Virginia · Charlottesville, Virginia · NCT04977180

• Evaluating Contrast-enhanced Spectral Mammography for Breast Cancer Screening

  This study is testing whether women with dense breast tissue prefer Contrast-enhanced Spectral Mammography over regular mammograms for their annual breast cancer screening.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT04904757

• Combination treatment for relapsed Peripheral T-Cell Lymphoma

  This study is testing a new combination treatment for people with relapsed Peripheral T-Cell Lymphoma to see if it works better than standard single-agent therapies.

  Recruiting at 5 sites Phase 2 University of Virginia · Long Beach, California and 5 other locations · NCT04747236

• Using spironolactone to normalize hormone levels in pubertal girls with high androgen levels

  This study is testing if the medication spironolactone can help normalize hormone levels in pubertal girls with high androgen levels by looking at how it affects their sleep and hormone pulses.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT04723862

• Imaging lung health effects of e-cigarette use

  This study is testing how e-cigarette use affects lung health in healthy young adults by using a special imaging technique to see how well their lungs work.

  Recruiting Phase 1/2 University of Virginia · Charlottesville, Virginia · NCT04662658

• Using 4D-MRI to improve cancer treatment planning

  This study is testing a new type of MRI that creates 3D movies of the lungs and liver while you breathe to see if it can help doctors plan better radiation treatments for lung and liver cancer patients.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT04657042

• Effects of exercise and medication on blood flow and insulin action in adults with metabolic syndrome

  This study is testing whether exercise, a diabetes medication called liraglutide, or a mix of both can improve blood flow and insulin function in adults with metabolic syndrome.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT04575844

• Examining the effects of dupilumab on asthma symptoms after a cold virus exposure

  This study is testing if the asthma medication dupilumab can help people with mild asthma avoid worse symptoms after catching a cold virus.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT04380038

• Using alanyl-glutamine to treat C. difficile infections

  This study is testing if taking alanyl-glutamine can help people with C. difficile infections recover better and prevent the infection from coming back.

  Recruiting at 2 sites Phase 2 University of Virginia · Charlottesville, Virginia and 1 other locations · NCT04305769

• Examining the effects of exercise and liraglutide on blood vessel function in Type 2 diabetes

  This study is testing whether exercise, a diabetes medication called liraglutide, or a mix of both can improve blood flow and how well the body uses insulin in people with Type 2 diabetes.

  Recruiting Phase 4 University of Virginia · Charlottesville, Virginia · NCT03883412

• Comparing two types of vaginal brachytherapy for endometrial cancer

  This study is testing two types of radiation treatments for early-stage endometrial cancer to see which one has a better impact on sexual health after surgery.

  Recruiting at 3 sites Phase 3 University of Virginia · Baltimore, Maryland and 2 other locations · NCT03785288

• Assessing Estradiol's Effect on Hormone Secretion in Women with Polycystic Ovary Syndrome

  This study is testing how a hormone called estradiol affects other hormones in women with polycystic ovary syndrome (PCOS) to see if they respond differently than women without PCOS.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT03401047

• Imaging-guided CRT using MRI and CT to personalize device placement

  A randomized approach tests whether guiding the CRT lead placement with MRI and CT information can improve outcomes for people with systolic heart failure.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT03398369

• Comparing two imaging techniques for lung ventilation in COPD patients

  This study is testing a new type of MRI using hyperpolarized Xenon-129 to see if it can better spot lung problems in people with COPD compared to the standard radioactive Xenon-133 scan.

  Recruiting Phase 1/2 University of Virginia · Charlottesville, Virginia · NCT03331302

• Durvalumab with pralatrexate, romidepsin, or oral 5‑azacitidine for peripheral T‑cell lymphoma

  This trial will test several combinations of durvalumab with pralatrexate, romidepsin, and/or oral 5‑azacitidine to find safe doses and see if they help adults with newly diagnosed or relapsed peripheral T‑cell lymphoma.

  Recruiting Phase 1/2 University of Virginia · Charlottesville, Virginia · NCT03161223

• Investigating hormone treatment effects in girls with high androgen levels

  This study is testing if a medication called spironolactone can help girls with high androgen levels by making another hormone treatment more effective in lowering certain hormone pulses.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT03068910

• Does short-term progesterone reduce waking LH pulse frequency in mid- to late-pubertal girls with and without hyperandrogenism?

  We will see if short-term progesterone lowers waking LH pulse frequency in mid- to late-pubertal girls with and without hyperandrogenism.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT00929006

NIH-funded research (newest 40 of 896)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• STeroids and enhanced Antibiotics for sepsis in Africa with HIV/TB (STARS)

  This grant tests whether adding steroids and stronger antibiotics helps adults with severe sepsis tied to HIV/TB in areas with high TB rates.

  NIH research University of Virginia · Charlottesville, United States · NIH-11617036

• Steroids and better antibiotics for sepsis in people with AIDS in Africa

  This study tests whether adding hydrocortisone and stronger antibiotics can improve survival for adults with sepsis who also have AIDS or advanced immune suppression in regions with high TB.

  NIH research University of Virginia · Charlottesville, United States · NIH-11617035

• Predictive tools to improve pediatric donor heart use

  A pediatric heart transplant grant is building data-driven tools to help doctors choose the best donor hearts for children.

  NIH research University of Virginia · Charlottesville, United States · NIH-11616970

• Microglia Help Finish Seizures and Heal the Brain

  Scientists are studying how brain immune cells (microglia) help end severe seizures and repair brain damage, with potential new ideas for people who have had status epilepticus.

  NIH research University of Virginia · Charlottesville, United States · NIH-11607998

• Small molecules that boost the 20S proteasome to fight Alzheimer’s and related dementias

  A new approach tests small molecules that activate the 20S proteasome to help neurons clear harmful proteins and slow the spread of disease in people affected by Alzheimer's and related dementias.

  NIH research University of Virginia · Charlottesville, United States · NIH-11606497

• Advanced genome and transcriptome analysis with long-read sequencing

  A researcher at a university is using long-read DNA and RNA sequencing to map complete genomes and transcriptomes for individuals to understand how genetic variations relate to disease risk.

  NIH research University of Virginia · Charlottesville, United States · NIH-11591256

• How the heart’s t-tubules respond to load in humans

  A study in adults will explore how mechanical load changes affect the heart’s t-tubule structure and key proteins, to understand why heart muscle loses strength.

  NIH research University of Virginia · Charlottesville, United States · NIH-11580802

• IgE antibodies to alpha-gal and heart disease in mice and people

  A study to understand how specific IgE antibodies against alpha-gal might influence the development and severity of atherosclerosis in humans and mouse models.

  NIH research University of Virginia · Charlottesville, United States · NIH-11567002

• MOSAIC: A hormone and microbiome model to predict sex-specific drug effects

  A new computer framework will model how hormones, metabolism, and gut-vaginal microbes together influence how drugs work differently in people of different sexes.

  NIH research University of Virginia · Charlottesville, United States · NIH-11563946

• Expanding epilepsy care access in Kenya with a shared medical record and task-sharing approach

  A project in Kenya aims to improve how people with epilepsy start and stay on antiseizure medicines by using a local electronic record system and training staff to share tasks that support care.

  NIH research University of Virginia · Charlottesville, United States · NIH-11540516

• Expanding Access to Epilepsy Care in Kenya to Reach More People

  A program in Kenya will test a practical, locally tailored plan to help people with epilepsy get treatment sooner, stay on their medications, and keep up with follow-ups.

  NIH research University of Virginia · Charlottesville, United States · NIH-11539576

• Understanding cryptosporidiosis in young children in Bangladesh

  A study in Bangladesh aims to learn how immunity and genes in children and the parasite influence who gets infected with cryptosporidiosis and how sick they become.

  NIH research University of Virginia · Charlottesville, United States · NIH-11527423

• Roles of intermediate filaments in nerve repair and sensory recovery

  This grant explores how specific neuron proteins help or hinder nerve fibers regrow after injury, with the aim of improving recovery of sensation and movement.

  NIH research University of Virginia · Charlottesville, United States · NIH-11527006

• Multi-organ tissue chips to study immune communication ex vivo

  Aiding researchers with a tiny, patient-friendly model that mimics how lymph nodes talk to organs to improve vaccines and treatments.

  NIH research University of Virginia · Charlottesville, United States · NIH-11521324

• Molecular details of the IgE response in alpha-gal allergy

  Scientists are building a first-in-kind set of human IgE antibodies from people with alpha-gal syndrome to understand exactly how the allergic protein interacts with the immune system.

  NIH research University of Virginia · Charlottesville, United States · NIH-11510399

• Innate inflammatory control of cachexia in chronic disease

  A research team is studying how inflammation drives cachexia in chronic disease using a parasite model to find therapies that could protect lean body mass without raising infection risk.

  NIH research University of Virginia · Charlottesville, United States · NIH-11508215

• IgE and tick bites: how our immune system reacts to tick saliva and may cause allergy or protection

  This grant looks at how our immune system’s IgE antibodies respond to tick saliva, which could explain allergies like alpha-gal syndrome or protection against future tick bites.

  NIH research University of Virginia · Charlottesville, United States · NIH-11493845

• How herpes simplex virus proteins help the virus reactivate in nerve cells

  Researchers are looking at viral proteins that help HSV-1 hide in and come back to life in nerve cells to hopefully protect people who carry the virus.

  NIH research University of Virginia · Charlottesville, United States · NIH-11493661

• How tiny cell vesicles may cause brain cavernous malformations

  This project looks at how changes inside blood-vessel cells in the brain lead to cerebral cavernous malformations, with special attention to people who have CCM3 gene defects.

  NIH research University of Virginia · Charlottesville, United States · NIH-11483416

• Preventing Growth Problems in Poor Children by Treating Small Intestine Bacteria

  A phase II effort in urban Bangladesh tests a treatment plan to stop growth failure and malnutrition in young children by addressing small intestinal bacterial overgrowth.

  NIH research University of Virginia · Charlottesville, United States · NIH-11478598

• Global network units study on women’s and children’s health in low-income settings

  A network of research units is studying health issues affecting mothers and young children in settings like Bangladesh to improve outcomes for infections, nutrition, and pregnancy-related health.

  NIH research University of Virginia · Charlottesville, United States · NIH-11478379

• Computational modeling of how external signals shape cell states using spatial and single-cell data

  A patient-relevant look at how signals from one cell influence another, using advanced tissue-wide and single-cell data to map how cells change their behavior.

  NIH research University of Virginia · Charlottesville, United States · NIH-11474018

• How microtubules help separate chromosomes during cell division

  This project looks at how the tiny internal scaffolding of cells (microtubules) moves and controls chromosomes during division to help improve cancer treatments.

  NIH research University of Virginia · Charlottesville, United States · NIH-11473196

• Transitioning HIV/TB Research at Tanzania’s National Infectious Diseases Institute

  A project in Tanzania aims to build stronger research administration and training to support HIV and TB research at a national infectious diseases institute.

  NIH research University of Virginia · Charlottesville, United States · NIH-11471397

• Interpreting genetic risk scores using biological data and family history

  This project will help make genetic risk scores easier to understand and more useful for people and families affected by conditions like autism, cancer, and heart disease by combining genetic, biological, and family information.

  NIH research University of Virginia · Charlottesville, United States · NIH-11469065

• Urine color test to check tuberculosis drug levels in children and adults

  This project uses a simple urine color test to see whether children and adults with TB are getting enough of key TB medicines like rifampin.

  NIH research University of Virginia · Charlottesville, United States · NIH-11468977

• Savoring Meditation for Chronic Low Back Pain patients

  A study tests a brief mindfulness-based practice called Savoring Meditation to help people with chronic low back pain feel better emotionally and manage pain in daily life.

  NIH research University of Virginia · Charlottesville, United States · NIH-11465428

• New alpha-helical proteins that control nitrogen use and virulence in harmful gut bacteria

  A small family of alpha-helical proteins found in diarrheagenic bacteria may regulate nitrogen metabolism and help these bacteria cause disease in the gut.

  NIH research University of Virginia · Charlottesville, United States · NIH-11464211

• Personalized CRT planning using advanced heart imaging and AI

  A scientist is testing a new AI-assisted imaging approach to help doctors choose the best CRT device (BIVP or LBBAP) for heart failure patients with specific conduction problems.

  NIH research University of Virginia · Charlottesville, United States · NIH-11461313

• Understanding how cilia disassembly and cell cycle control affect human disease

  Researchers are studying how problems in cilia disassembly and cell cycle control caused by human genetic variants may contribute to developmental issues and cancers.

  NIH research University of Virginia · Charlottesville, United States · NIH-11459765

• How the brain immune protein CLEC7A may affect Alzheimer's

  Researchers are testing whether changing a brain immune protein called CLEC7A can help brain immune cells clear Alzheimer’s plaques for people with or at risk for Alzheimer’s disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11457046

• Addressing financial hardship for cancer patients and their caregivers

  A new NIH-funded project aims to develop a practical, adaptable program to reduce financial toxicity for people with cancer and those who care for them.

  NIH research University of Virginia · Charlottesville, United States · NIH-11453762

• How the APOE4 gene affects brain blood flow, sleep, and waste clearance

  This work looks at whether the APOE4 gene variant changes brain blood flow, disrupts sleep, and reduces the brain's ability to clear waste in people at higher genetic risk for Alzheimer's.

  NIH research University of Virginia · Charlottesville, United States · NIH-11453131

• Tools to find and measure cancer drug targets

  Creating new chemical probes to find which proteins cancer drugs attach to and how much they bind, to help people with cancer.

  NIH research University of Virginia · Charlottesville, United States · NIH-11451959

• Neuroimmune control of kidney injury using noninvasive ultrasound

  A new approach uses targeted ultrasound to gently stimulate nerves and immune signals to help the kidney recover after injury.

  NIH research University of Virginia · Charlottesville, United States · NIH-11449889

• Optimizing personal lifestyle support for adults on next-gen obesity drugs

  A big study will test which parts of a lifestyle program help adults taking new obesity medications do better in weight and health over a year.

  NIH research University of Virginia · Charlottesville, United States · NIH-11449807

• How blocking UFMylation could boost immune attack on breast cancer

  A study in mice tests whether blocking UFMylation can make breast tumors more visible to the immune system and help immunotherapies work better.

  NIH research University of Virginia · Charlottesville, United States · NIH-11449400

• Understanding how RNA marks (m6A) influence lung cancer risk

  A study to find RNA modification signals that are linked to lung cancer risk in people of European and African ancestry, using genetic and multi-omics data.

  NIH research University of Virginia · Charlottesville, United States · NIH-11449219

• Optimizing a Digital Program to Cut Sugary Drink and Added-Sugar Intake in Rural Appalachia

  A fully digital, self-guided program helps adults in rural Appalachia reduce sugary drinks and foods high in added sugar to support healthier weight.

  NIH research University of Virginia · Charlottesville, United States · NIH-11448002

• Understanding how aging affects myelin and oligodendrocytes in Alzheimer's disease

  This project studies how aging changes brain cells called oligodendrocytes and myelin to better understand and treat Alzheimer's-related cognitive decline.

  NIH research University of Virginia · Charlottesville, United States · NIH-11447693

Quick answers

How many clinical trials run by University of Virginia are recruiting right now?

93, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (90 trials), Tanzania (2 trials), United Kingdom (1 trial), Kenya (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Early Phase 1: 9, Phase 4: 8, Phase 1: 6. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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