High-intensity interval training and causes of low cardiorespiratory fitness in people with ANOCA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study will enroll 25 adults with angina and no obstructive coronary artery disease confirmed by invasive or CT coronary angiography. Participants will complete baseline cardiopulmonary exercise testing (CPET) and questionnaires on symptoms and quality of life, then undergo a four-week remotely monitored HIIT program with wearable monitoring. CPET and the same questionnaires will be repeated after training to measure changes in peak VO2 and to define CPET phenotypes that reflect cardiac, ventilatory, and muscle contributors to exercise limitation. Validated instruments including the Seattle Angina Questionnaire, SF-36, MacNew, CAQ, WLQ, and DASI will be used to capture symptom burden and functional status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-85
* ANOCA (Anginal symptoms of chest pain or exertional dyspnea suspected to be from myocardial ischemia Invasive or CT coronary angiogram without obstructive epicardial CAD (≥50% left main or ≥70% other epicardial stenosis or fractional flow reserve ≤0.80)
* Able to use the wearable and participate in a remote exercise program
* Able to participate in intermittent high-intensity training.
* Able to perform cardiopulmonary exercise testing (CPET)
* Able to provide Health-related quality of life questionnaire (HRQOL)
* Participants must be able to understand and provide informed consent in English and complete the study questionnaire in English

Exclusion Criteria:

* Systolic heart failure (LVEF \<50% or NYHA class III symptoms)
* Prior myocardial infarction, coronary revascularization
* Inability to safely undergo cardiopulmonary exercise testing, based on investigator's judgment
* Pregnancy (due to unknown effects on CPET exercise markers)
* Inability to provide informed consent
* Life expectancy \<1 year
* Prisoners
* Cognitively impaired
* Non-English speaking

Where it's running

• University of Virginia Health System
  Charlottesville, Virginia, United States Recruiting

Study contacts

• Principal investigator: Jamieson M Bourque, MD, MHS — University of Virginia
• Study coordinator: Rahel Askari
• Email: rahel.askari@uvahealth.org
• Phone: 434-243-7195

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.