Comparing two imaging techniques for lung ventilation in COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to compare hyperpolarized Xenon-129 MRI with radioactive Xenon-133 scintigraphy to assess lung ventilation defects in patients with Chronic Obstructive Pulmonary Disease (COPD). The study will optimize imaging parameters for future trials and evaluate the effectiveness of hyperpolarized Xenon-129 MRI in detecting small ventilation obstructions that may be missed by the traditional scintigraphy method. Participants will undergo both imaging techniques to determine their concordance in identifying lung function issues.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must have a diagnosis of COPD
* at their clinical baseline on the day of imaging
* must be clinically stable in order to participate in the study.
* COPD subjects will be categorized according to the GOLD
* Current/Former SmokerSubjects
* must have a smoking history ≥ 10 pack years

Exclusion Criteria:

* Dx of asthma
* Continuous oxygen use at home
* Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging
* FEV1 percent predicted less than 25%
* Pregnancy or lactation
* Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning
* Subjects with any implanted device that cannot be verified as MRI compliant will be excluded
* Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches
* History of congenital cardiac disease, chronic renal failure, or cirrhosis
* Inability to understand simple instructions or to hold still for approximately 10 seconds
* History of respiratory infection within 2 weeks prior to the MR scan
* History of MI, stroke and/or poorly controlled hypertension.

Where it's running

• University of Virginia Health System
  Charlottesville, Virginia, United States Recruiting

Study contacts

• Principal investigator: Yun M Shim, MD — University of Virginia
• Study coordinator: Sarah Struchen, RN
• Email: SS8YM@hscmail.mcc.virginia.edu
• Phone: 4342436074

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.