Examining the effects of exercise and liraglutide on blood vessel function in Type 2 diabetes
Official title: Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)
Run by University of Virginia · NCT03883412 · Data updated 2026-11-12
This study is testing whether exercise, a diabetes medication called liraglutide, or a mix of both can improve blood flow and how well the body uses insulin in people with Type 2 diabetes.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University of Virginia Academic / other |
| Locations | 1 site (Charlottesville, Virginia) |
| Status | Recruiting |
| Started | February 28, 2019 |
| Main results expected | June 2027 |
| Study ends | December 2027 |
| Registry record updated | August 12, 2026 |
| Trial ID | NCT03883412 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 21-60 with Type 2 diabetes who have not previously used GLP-1 receptor agonists or DPP-4 inhibitors.
✕Probably not a fit
Patients currently taking insulin or with significant cardiovascular or metabolic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the impact of exercise training, liraglutide treatment, or a combination of both on vascular function and insulin sensitivity in individuals with Type 2 diabetes. Participants will be randomly assigned to one of three groups: exercise only, liraglutide only, or both interventions. The study aims to determine if these treatments can enhance blood flow and improve metabolic responses in muscle over a 16-week period. The primary outcomes include changes in cardiac and muscle capillary blood volume and overall vascular function.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for enhancing vascular health and insulin sensitivity in patients with Type 2 diabetes.
How similar studies have gone: Previous studies have shown promising results with exercise and GLP-1 receptor agonists in improving metabolic health, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 21-60 * A1C ≤ 8.5% * Never on GLP-1RA (eg: exenatide, liraglutide) or DPP4I ( eg: Sitaglipton) * On stable dose of oral hypoglycemic agents \>4 months * On stable dose of other medications for \>4 months Exclusion Criteria: * Taking Insulin * Smoking presently or in the past 6 months * BP \>160/90 * BMI \>35 * Family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome * History of congestive heart failure, ischemic heart disease, severe pulmonary disease, liver or kidney disease. * Any vascular disease such as myocardial infarction, stroke, peripheral vascular disease * Presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam by PI). * Pregnant or breastfeeding. * Known hypersensitivity to perflutren (contained in Definity)
Where it's running
-
University of Virginia
Charlottesville, Virginia, United States Recruiting
Study contacts
- Principal investigator: Zhenqi Liu, MD — University of Virginia, Department of Endocrinoolgy
- Study coordinator: Lee Hartline, MEd
- Email: lmh9d@virginia.eud
- Phone: 434-924-5247
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.