Using a genetic test to guide blood thinner prescriptions after a stroke
Official title: Implementation of Onsite Rapid CYP2C19 Assay for Genotype Guided Dual Antiplatelet Therapy After Acute Ischemic Stroke
Run by University of Virginia · NCT06292117 · Data updated 2026-11-12
This study is testing whether a quick genetic test can help doctors choose the right blood thinners for patients who have had a stroke or mini-stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 350 (estimated) |
| Sponsor | University of Virginia Academic / other |
| Locations | 1 site (Charlottesville, Virginia) |
| Status | Recruiting |
| Started | April 16, 2024 |
| Main results expected | June 2026 |
| Study ends | October 2026 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT06292117 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older who present with symptoms of acute ischemic stroke or transient ischemic attack and are eligible for dual antiplatelet therapy.
✕Probably not a fit
Patients who are receiving therapeutic anticoagulation or have contraindications to dual antiplatelet therapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to implement a rapid genetic test for CYP2C19 to guide the prescription of dual antiplatelet therapy in patients who have experienced an acute ischemic stroke or transient ischemic attack. The study will evaluate the feasibility and acceptability of using this genetic test in an acute inpatient setting and analyze its impact on prescribing patterns for blood thinners. Patients will undergo rapid genotyping to determine their CYP2C19 status, and results will be integrated into electronic health records to inform clinical decision-making.
Why it matters
Potential benefit: If successful, this approach could lead to more effective prevention of recurrent strokes by ensuring patients receive the most suitable blood thinner based on their genetic profile.
How similar studies have gone: Other studies have shown success with similar genetic-guided approaches in optimizing antiplatelet therapy, indicating a promising avenue for precision medicine.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women at least 18 years of age * Presenting with symptoms of acute ischemic stroke or transient ischemic attack and without contraindications to dual antiplatelet therapy at time of clinical research coordinator screening * Presenting within 24 of symptom onset; or, within 24-96 hours of symptom onset IF planned to receive or already on dual antiplatelet therapy Exclusion Criteria: * Receiving therapeutic anticoagulation or clear indication for initiation of anticoagulation after event (e.g., known atrial fibrillation) * History of allogeneic bone marrow transplant * History of liver transplant * Subject who is unable to consent and does not have a surrogate available to consent on their behalf
Where it's running
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University of Virginia
Charlottesville, Virginia, United States Recruiting
Study contacts
- Principal investigator: Rachael M Stone, PharmD — University of Virginia
- Study coordinator: Andrew Weko, MPH
- Email: crx3qp@uvahealth.org
- Phone: 434-297-6777
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.