Using magnesium and riboflavin to treat headaches after a concussion
Official title: Magnesium and Riboflavin Treatment for Post-Concussion Headache
Run by University of Virginia · NCT06260072 · Data updated 2026-11-12
This study tests if taking magnesium and riboflavin supplements can help people with concussions feel better by reducing headache pain and how long the headaches last.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 108 (estimated) |
| Sponsor | University of Virginia Academic / other |
| Locations | 1 site (Charlottesville, Virginia) |
| Status | Recruiting |
| Started | February 10, 2020 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | March 27, 2025 |
| Trial ID | NCT06260072 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals who have recently been diagnosed with a concussion and are able to swallow capsules.
✕Probably not a fit
Patients with severe complications from their concussion, such as cranial bleed or skull fractures, will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate whether magnesium and riboflavin supplements can alleviate headache pain and reduce the duration of headaches in individuals diagnosed with a concussion. Participants will be randomly assigned to receive either the active supplements or a placebo for 14 days, taking one capsule daily. Throughout the study, participants will maintain a diary to track their symptoms and will attend three follow-up visits, either by phone or in person, to monitor their progress.
Why it matters
Potential benefit: If successful, this treatment could provide a non-invasive option for managing post-concussion headaches.
How similar studies have gone: While the specific combination of magnesium and riboflavin for post-concussion headaches is novel, there is existing research on the individual effects of these supplements on headache management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Seen at University of Virginia Student Health and Wellness Center or Emergency Department for Initial Visit for Concussion; * Less than 3 days have elapsed since their injury; * Able to swallow capsules Exclusion Criteria: * Concussion complicated by cranial bleed, skull fracture, additional severe injury; * Kidney disfunction or failure; * Significant gastro-intestinal dysfunction; * Varsity Athlete; * Two or more previous concussions; * Women who are pregnant or breast feeding; * Taking tetracycline, fluoroquinolone, iron digoxin, chlorpromazine or penicillamine
Where it's running
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University of Virginia Student Health and Wellness Center
Charlottesville, Virginia, United States Recruiting
Study contacts
- Principal investigator: Stephanie Hartman, MD — UVA Student Health and Wellness
- Study coordinator: Stephanie Hartman, MD
- Email: slm8nh@virginia.edu
- Phone: 434-924-5362
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Improving access to specialty care for concussion patients
This study is testing a new mobile health program to help concussion patients get better care faster and improve their recovery by allowing them to share their symptoms daily with doctors.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.