Imaging lung health effects of e-cigarette use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the health effects of e-cigarettes on the lungs of healthy young adults using a novel imaging technique called hyperpolarized xenon-129 MRI. The study will assess lung function and gas exchange by quantifying regional ventilation and gas uptake in the lungs. Participants will include e-cigarette users and non-smokers, with careful monitoring of their health status and lung function. The goal is to provide insights into the potential pulmonary risks associated with e-cigarette use, which is currently poorly understood.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male and female subjects 21-30 years of age
2. At baseline health with no recent illnesses or medical conditions that would preclude enrollment as assessed by the Principal Investigator
3. Ability to understand a written informed consent form and comply with the requirements of the study.
4. E-cigarette use for more than 6 months preceding the date of enrollment and less than a 5 pack year smoking history (e-cigarette users) OR less than a 5 pack year smoking history (non-smoker group).
5. No diagnosis of any lung disease (pre-bronchodilator FEV1/FVC normal on the day of screening defined by \> 95thCI of NHANES III, ATS/ERS guideline)

Exclusion Criteria:

1. History of any lung disease
2. Control (non-smoking) group: History of illegal drug use by inhalation
3. History of CNS disease including stroke and dementia, end-stage liver disease, coronary artery disease, renal failure
4. Acute infection of any kind in the previous 6 weeks
5. Pregnancy or a possibility of pregnancy
6. Anemia
7. Inability to undergo MR imaging based on the standard clinical criteria for MRI

Where it's running

• Snyder Building 480 Ray C. Hunt Drive
  Charlottesville, Virginia, United States Recruiting

Study contacts

• Principal investigator: Yun M shim, MD — University of Virginia
• Study coordinator: Roselove Asare
• Email: rnn3b@virginia.edu
• Phone: 434-243-6074

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.