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Clinical trials and research at University of Sao Paulo

• 53Clinical trials
• 4NIH research projects
• 1New in 30 days
• 1Country

Newest trials

All recruiting trials (53)

• Smartphone-supported single-session psychotherapy for postpartum depression

  A single online therapy session plus four weeks of app-based support is being tested to see if it reduces depressive symptoms in postpartum women compared with a waitlist.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07925762

• S-ICD Eligibility Over Time in Arrhythmogenic Cardiomyopathy

  This study checks whether adults with arrhythmogenic cardiomyopathy stay eligible for a subcutaneous ICD over 18 months.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07849764

• Molecular autopsy to find genetic causes of sudden death in young people

  This study tests a post-m death genetic workflow to see if a genetic cause can be found in people aged 1–50 who died suddenly and to identify relatives who may need heart screening.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07849738

• Foam Sclerotherapy With or Without Transdermal Laser for Small Veins in the Legs

  This study tests whether adding a transdermal Nd:YAG laser after foam sclerotherapy helps treat small leg veins in women compared with foam alone.

  Recruiting Phase 4 University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07793630

• Ketone and Carbohydrate Supplementation in Endurance Cycling

  This study tests whether adding ketones to a carb plan helps amateur endurance cyclists perform better and think more clearly during long, exhausting rides.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07792876

• Platelets and plasma lipids as markers and targets in thrombosis

  This study tests whether two lipid emulsion formulations change platelet clumping in healthy volunteers age 40 and up who do not have heart disease.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07774845

• Gummy smile correction with esthetic crown-lengthening surgery

  This study tests whether esthetic crown-lengthening surgery can stabilize gum tissue in adults with altered passive eruption and excessive gingival display.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07762482

• Single dose ayahuasca in adults with psychogenic non-epileptic seizures

  This open-label study tests whether a single dose of ayahuasca is safe and what effects it has in adults with psychogenic non-epileptic seizures who are under care.

  Recruiting Phase 1/2 University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07747324

• Outpatient respiratory physiotherapy for infants with bronchiolitis

  This study tests whether outpatient respiratory physiotherapy can reduce hospitalizations for infants with mild-to-moderate acute viral bronchiolitis in Sorocaba, Brazil.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07682844

• Telerehabilitation to boost arm recovery after stroke in Brazil

  In people who recently had a stroke, this study tests whether adding structured arm-focused telerehabilitation to usual care helps improve arm function compared with usual care alone.

  Recruiting Phase 2 University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07646522

• Volume-stable collagen matrix vs graft for multiple gingival recessions

  This study tests whether a volume-stable collagen matrix can cover exposed roots as well as a traditional graft, in adults with multiple gingival recessions.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07613775

• Mechanochemical ablation versus ultrasound-guided polidocanol foam sclerotherapy for great saphenous vein varicose veins

  This compares mechanochemical ablation and ultrasound-guided polidocanol foam sclerotherapy to see which better closes the great saphenous vein and improves symptoms in adults with symptomatic varicose veins.

  Recruiting Phase 4 University of Sao Paulo · São Paulo, São Paulo · NCT07561320

• Polynucleotide and hyaluronic acid gel with xenogeneic bone graft for treating intrabony periodontal defects

  This study tests whether adding a polynucleotide/hyaluronic acid gel plus a xenogeneic bone graft to open-flap debridement helps adults with stage III/IV periodontitis and intrabony defects heal better.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07522684

• Lifestyle program to prevent obesity and eating disorders in transgender and gender-diverse adolescents

  This project will test whether a 6-month gender-affirming lifestyle program with monthly group sessions for adolescents and caregivers plus weekly support messages helps transgender and gender-diverse 10–14-year-olds prevent obesity and eating disorders and improve quality of life.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07466069

• Adding laser-based antimicrobial therapy to deep cleaning and tongue scraping for bad breath in people with type 2 diabetes and severe gum disease

  This trial tests whether adding antimicrobial photodynamic therapy to standard deep cleaning and tongue scraping reduces bad breath in people with type 2 diabetes and advanced periodontitis.

  Recruiting University of Sao Paulo · Bauru, São Paulo · NCT07463859

• Creatine plus resistance training to improve muscle loss after androgen-deprivation therapy for prostate cancer

  This trial will test whether daily creatine plus supervised resistance training for 12 weeks helps men on androgen-deprivation therapy for prostate cancer keep or restore muscle mass, strength, and physical function compared with training plus placebo.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07463092

• Intraoperative cryoanalgesia versus thoracic epidural block for pain control after minimally invasive pectus excavatum repair

  This trial will try intraoperative cryoanalgesia versus a thoracic epidural block to see which controls pain better after minimally invasive pectus excavatum repair in patients aged 13 and older.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07431632

• Transcranial alternating current stimulation for generalized anxiety disorder and chronic insomnia

  This study will try 20 sessions of transcranial alternating current stimulation (tACS) with the Nexalin device to see if it improves anxiety and sleep in adults with generalized anxiety disorder and chronic insomnia.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07429578

• Adding lacosamide to treatment for major depressive episodes in bipolar I and II

  This trial will test whether adding lacosamide to a person's current medication helps reduce depressive symptoms in adults with treatment-resistant bipolar I or II depression.

  Recruiting Phase 3 University of Sao Paulo · São Paulo, São Paulo · NCT07412132

• Single‑visit light plus ultrasound treatment for small nodular basal cell carcinoma

  This trial will test a single‑visit combination of photodynamic therapy with low‑intensity ultrasound (sono‑PDT) to treat adults who have small nodular basal cell carcinoma lesions.

  Recruiting Phase 3 University of Sao Paulo · Jaú, São Paulo · NCT07381972

• Noninvasive neuromodulation for people with traumatic brain injury and healthy volunteers

  We will try a noninvasive radioelectric neuromodulation (REAC) treatment to see if it changes brain waves in people with diffuse axonal injury after severe TBI and in healthy volunteers.

  Recruiting Phase 2 University of Sao Paulo · São Paulo, São Paulo · NCT07373366

• Comparing ayahuasca and esketamine for premenstrual symptoms

  This study tests whether a single oral dose of ayahuasca or esketamine can reduce premenstrual symptoms in healthy women.

  Recruiting University of Sao Paulo · Ribeirão Preto · NCT07317232

• Comparing ayahuasca and esketamine effects on women's body perception

  This will test whether a single oral dose of ayahuasca or esketamine changes how healthy women perceive their bodies.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07317219

• Single-dose ayahuasca versus esketamine for PTSD

  This study will try a single dose of ayahuasca or esketamine to see if it quickly reduces symptoms in adults with PTSD.

  Recruiting Phase 2 University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07317206

• Wearable cardiac monitoring for early arrhythmia detection and remote management

  This project will try a smartwatch-based system to spot arrhythmias early and help manage adults with chronic or recently treated heart problems.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07174206

• Physiotherapy and cold‑pack treatment for first-time mothers with perineal tears after vaginal delivery

  This will test whether pelvic floor muscle exercises plus cryotherapy started right after birth reduce perineal pain for first-time mothers who had a grade 2 or higher tear or an episiotomy.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT07170007

• AI helper (Tia Bete) on WhatsApp to assist with carb counting and insulin dosing for people with type 1 diabetes

  This trial will test whether an AI tool delivered via WhatsApp can help children and adults with type 1 diabetes count carbohydrates and adjust insulin doses more accurately.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT07150052

• Dietary guidance and probiotics for pelvic pain in women with endometriosis and IBS

  This trial will try dietary guidance and Lactobacillus probiotics to see if they reduce chronic pelvic pain in women who have both endometriosis and irritable bowel syndrome.

  Recruiting University of Sao Paulo · Catanduva, São Paulo · NCT07149519

• Esketamine or Crisis Planning Added to Usual Care for Suicidality in Brazil

  This trial tests whether a single esketamine infusion or a single Crisis Response Planning session, added to enhanced treatment as usual, can reduce future suicide-related events in adolescents and adults in Indaiatuba, Brazil.

  Recruiting Phase 4 University of Sao Paulo · Indaiatuba, São Paulo · NCT07120477

• Eszopiclone for lowering blood pressure in adults with insomnia and high blood pressure

  This study tests whether eszopiclone can improve sleep and lower 24-hour ambulatory blood pressure in adults aged 30–75 who have insomnia and treated hypertension.

  Recruiting Phase 4 University of Sao Paulo · São Paulo, São Paulo · NCT07018557

• Comparing vasopressin and norepinephrine for treating low blood pressure after heart surgery

  This study is testing whether vasopressin or norepinephrine works better to treat low blood pressure in patients who develop complications after heart surgery.

  Recruiting Phase 4 University of Sao Paulo · São Paulo · NCT06934798

• Comparing point-of-care and laboratory testing for heart attack diagnosis

  This study is testing if a quick bedside test for heart attacks can help patients with chest pain leave the hospital faster than using the traditional lab tests.

  Recruiting University of Sao Paulo · São Paulo · NCT06861582

• Evaluating oral health among students at the University of São Paulo

  This study looks at the oral health of current and former students at the University of São Paulo to see how it affects their academic performance and attendance over five years.

  Recruiting University of Sao Paulo · São Paulo · NCT06853639

• Aerobic exercise to improve sensory, muscle, and psychosocial symptoms in women with migraine

  This trial will test whether supervised aerobic exercise plus one pain neuroscience education session helps women aged 18–48 with migraine reduce disability and improve sensory, musculoskeletal, and psychosocial symptoms.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT06716489

• Evaluating a method for preserving jawbone after tooth extraction

  This study is testing a new way to keep the jawbone strong after tooth removal to see if it helps people get better dental implants later on.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06698276

• Evaluation of customized dental implants over three years

  This study is testing how well personalized dental implants work for patients over three years compared to regular implants, looking at things like comfort and how well they last.

  Recruiting University of Sao Paulo · São Paulo · NCT06576284

• Physical exercise to improve cognitive function in bipolar disorder patients

  This study is testing if a structured exercise program can help improve thinking skills and quality of life for people with bipolar disorder.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06560749

• Program to lower cardiovascular risk with a nutrition plan for people with bipolar disorder

  This trial will test whether a dietary program based on the Brazilian Dietary Guidelines can lower cardiovascular risk in adults with bipolar disorder who are on stable medication.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06488573

• Psychoeducational program for treating depression

  This study tests if adding a six-week group program that teaches coping strategies can help people with Major Depressive Disorder feel better and improve their quality of life.

  Recruiting University of Sao Paulo · São Paulo · NCT06467474

• Effects of Dapagliflozin on Heart Health in Patients with Acute Coronary Syndromes

  This study is testing if dapagliflozin, a diabetes medication, can improve heart health in people who have just had a heart attack.

  Recruiting Phase 2/3 University of Sao Paulo · São Paulo, São Paulo · NCT06286878

• Using inorganic nitrate to treat high blood pressure in pregnant women

  This study is testing if taking inorganic nitrate can help pregnant women with high blood pressure improve their blood pressure and support their baby's health.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT06105775

• CD19-directed CAR-T cell therapy for relapsed leukemia and lymphoma

  This study is testing a new CAR-T cell therapy to see if it can help people with hard-to-treat leukemia and lymphoma feel better.

  Recruiting at 5 sites Phase 1/2 University of Sao Paulo · Campinas, São Paulo and 4 other locations · NCT06101381

• Using light therapy to improve gum health in obese patients with periodontitis

  This study is testing whether adding light therapy to regular gum treatment can help improve gum health in obese patients with gum disease.

  Recruiting University of Sao Paulo · Bauru, São Paulo · NCT06073704

• Observational study on postoperative complications in pediatric surgery in Latin America

  This study looks at the complications that can happen after surgery in kids under 18 in Latin America to see how common they are and what might cause them.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT05934682

• Biofeedback versus vaginal palpation to teach voluntary pelvic floor muscle contractions

  This test compares biofeedback and vaginal palpation to see which better helps women with urinary incontinence who cannot currently contract their pelvic floor muscles learn a correct contraction.

  Recruiting University of Sao Paulo · Ribeirão Preto, São Paulo · NCT05194137

• Using brain stimulation to help COVID-19 patients with autoimmune diseases

  This study is testing if a type of brain stimulation can help COVID-19 patients with autoimmune diseases feel better by reducing their fatigue and pain.

  Recruiting University of Sao Paulo · São Paulo · NCT04890483

• Using brain stimulation to help patients with autoimmune muscle diseases

  This study is testing if a new brain stimulation treatment combined with exercise can help people with autoimmune muscle diseases feel stronger and improve their quality of life.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT04678635

• Predicting naltrexone response in gaming disorder using eye tracking

  A 12-week, double‑blind study will test whether eye-tracking can predict which individuals with gaming disorder respond to naltrexone.

  Recruiting Phase 2 University of Sao Paulo · São Paulo, São Paulo · NCT04649892

• Using brain stimulation to treat muscle weakness in autoimmune myopathy patients

  This study is testing if a new type of brain stimulation can help people with autoimmune myopathy improve their muscle strength and overall health.

  Recruiting University of Sao Paulo · São Paulo · NCT03749538

• Early immunosuppressive treatment for Vogt-Koyanagi-Harada disease

  This project tests whether starting high-dose corticosteroids plus immunosuppressive drugs at disease onset helps people with Vogt-Koyanagi-Harada disease control inflammation and protect vision.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT03399175

• Optimizing treatment for idiopathic inflammatory myopathies

  This study is testing whether a combination of two treatments or just one can help people with idiopathic inflammatory myopathies feel better when they first start their treatment.

  Recruiting University of Sao Paulo · São Paulo · NCT03092180

• Comparing Latarjet and Modified Eden-Hybinette shoulder stabilization surgeries

  This tests whether Latarjet or Modified Eden‑Hybinette surgery better prevents repeat anterior shoulder dislocations in people with recurrent traumatic dislocation and significant glenoid bone loss.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT02913352

• Using targeted radiation therapy for liver tumors that can't be surgically removed

  This study is testing if a special type of radiation therapy can help patients with certain types of cancer who have liver tumors that can't be surgically removed.

  Recruiting Phase 2 University of Sao Paulo · São Paulo, São Paulo · NCT02185443

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• ADHD and educational achievement across different Brazilian communities

  A large study in Brazilian adults will look at how ADHD and educational outcomes are connected, using genetic data to understand differences across diverse urban regions.

  NIH research University of Sao Paulo · Sao Paulo, Brazil · NIH-11376059

• Targeting a parasite enzyme to find new Chagas disease medicines

  Trying to block a key enzyme in the Chagas parasite to create new medicines for people with Chagas disease.

  NIH research University of Sao Paulo · Sao Paulo, Brazil · NIH-11143812

• Understanding the link between education and ADHD in different communities

  This project explores how genes and environment together shape the connection between ADHD and educational success in adults from diverse backgrounds.

  NIH research University of Sao Paulo · Sao Paulo, Brazil · NIH-11091533

• Finding new treatments for Chagas disease by targeting a specific enzyme.

  This study is looking for new treatments for Chagas disease by focusing on a key enzyme that the parasite needs to survive, with the hope that this could lead to better options for people living with the condition.

  NIH research University of Sao Paulo · Sao Paulo, Brazil · NIH-10873353

Quick answers

How many clinical trials run by University of Sao Paulo are recruiting right now?

53, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in Brazil. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 5, Phase 1/2: 2, Phase 3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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