Comparing ayahuasca and esketamine for premenstrual symptoms
Official title: Effects of a Single Dose of Ayahuasca or Esketamine on the Menstrual Cycle and Premenstrual Symptoms: a Randomized, Double-Blind Study
Run by University of Sao Paulo · NCT07317232 · Data updated 2026-11-12
This study tests whether a single oral dose of ayahuasca or esketamine can reduce premenstrual symptoms in healthy women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 20 (estimated) |
| Sponsor | University of Sao Paulo Academic / other |
| Locations | 1 site (Ribeirão Preto) |
| Status | Recruiting |
| Started | December 20, 2025 |
| Main results expected | June 2026 |
| Study ends | July 2026 |
| Registry record updated | January 5, 2026 |
| Trial ID | NCT07317232 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy women who experience premenstrual symptoms, have no psychiatric or other medical comorbidities, and can attend the Ribeirão Preto site are ideal candidates.
✕Probably not a fit
Women with psychiatric disorders, other medical comorbidities, or who cannot travel to the study site would be ineligible and unlikely to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a double-blind, randomized interventional trial that gives a single oral dose of either ayahuasca or esketamine to healthy female volunteers with premenstrual symptoms. Participants are randomly assigned and both participants and staff are blinded to the assignment. The protocol excludes individuals with psychiatric or other medical comorbidities and is conducted at Hospital das Clínicas da FMRP-USP in Ribeirão Preto, Brazil. The registry entry does not provide detailed outcome measures or follow-up timing.
Why it matters
Potential benefit: If successful, this could provide a rapid, single-dose option to relieve premenstrual symptoms.
How similar studies have gone: Both ayahuasca and esketamine have shown rapid antidepressant effects in prior small studies, but their use specifically for premenstrual symptoms is largely untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy volunteers Exclusion Criteria: * psychiatric and other medical comorbidities
Where it's running
-
Hospital das Clínicas da FMRP-USP
Ribeirão Preto, Brazil Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.