Comparing ayahuasca and esketamine effects on women's body perception
Effects of a Single Dose of Ayahuasca or Esketamine on Body Image Perception in Women: a Randomized, Double-blind Study
NA · University of Sao Paulo · NCT07317219
This will test whether a single oral dose of ayahuasca or esketamine changes how healthy women perceive their bodies.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | Female |
| Sponsor | University of Sao Paulo (other) |
| Locations | 1 site (Ribeirão Preto, São Paulo) |
| Trial ID | NCT07317219 on ClinicalTrials.gov |
What this trial studies
This is a double-blind, randomized trial that gives a single oral dose of either ayahuasca or esketamine to healthy female volunteers and compares changes in body-image perception. Participants are screened to exclude psychiatric and other medical comorbidities and are monitored at Hospital das Clínicas da FMRP-USP in Ribeirão Preto, São Paulo. Outcomes will focus on perceptual and self-report measures of body image collected before and after dosing to capture acute effects. The design aims to isolate drug-specific effects on body perception while minimizing confounding from underlying illness.
Who should consider this trial
Good fit: Healthy adult women without psychiatric or significant medical conditions who can travel to and attend in-person sessions at the study site are the intended participants.
Not a fit: People with psychiatric or other medical comorbidities, men, pregnant or breastfeeding individuals, or those unwilling to receive psychoactive treatments are unlikely to benefit from participating.
Why it matters
Potential benefit: If successful, the results could reveal rapid-acting ways to alter body perception and inform new approaches for treating body-image disturbances.
How similar studies have performed: Prior research shows ketamine and classical psychedelics can rapidly change perception and mood, but direct randomized comparisons of ayahuasca and esketamine on body-image perception are novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy volunteers Exclusion Criteria: * psychiatric and other medical comorbidities
Where this trial is running
Ribeirão Preto, São Paulo
- Hospital das Clínicas da FMRP-USP — Ribeirão Preto, São Paulo, Brazil (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Women Volunteers