Ketone and Carbohydrate Supplementation in Endurance Cycling

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, double-blind, crossover trial, amateur endurance cyclists will complete three 3-hour cycling sessions under different nutrition conditions: carbohydrate alone, carbohydrate plus ketone, and placebo. Researchers will measure cognitive performance with computer tests, physical output by distance covered, and blood biomarkers to understand metabolic responses. PBMCs will be cultured with and without inflammatory triggers to explore neuro-immune interactions. The goal is to see if ketones can support performance and brain function during prolonged exercise beyond energy supply alone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Amateur male cyclists;
* At least 2 years of cycling experience;
* At least 5 hours of endurance cycling training per week;
* VO2max of at least 50 mL/kg/min.

Exclusion Criteria:

* Confirmed diagnosis of COVID-19 by PCR or rapid antigen test within the last 12 months;
* Symptoms compatible with COVID-19 within the last six months;
* Smokers;
* Alcoholics;
* Presence of neurological, immune, or muscular diseases;
* Use of psychoactive medications in the last year;
* Use of any acute medication prior three days each visit that possible could affect the experiment such as stool-altering medications and non-steroidal anti-inflammatory drugs;
* Confirmed gastrointestinal infections, diseases, or disorders (e.g., coeliac disease, inflammatory bowel disease, irritable bowel syndrome, diverticular disease, gastroesophageal reflux disease);
* Medical history of gastrointestinal surgery, or any other self-reported gastrointestinal issues;
* Within the previous three months, if they had consumed substances that could affect gastrointestinal integrity or followed gastrointestinal-targeted dietary regimes;
* Participants with any food allergy should be excluded of this study.

Where it's running

• School of Physical Education and Sport of Ribeirão Preto - University of São Paulo
  Ribeirão Preto, São Paulo, Brazil Recruiting

Study contacts

• Principal investigator: Joao P Floriano — University of Sao Paulo
• Study coordinator: João P. Floriano, Bachelor of Nutrition
• Email: jp_floriano@usp.br
• Phone: +551699772-5355

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Ketone plus protein after workouts to see if it helps keep and build muscle in young men

  This study tests whether taking a ketone supplement with protein after resistance exercise helps better retain amino acids and reduce muscle breakdown in young, trained men.

  Recruiting McGill University · Montreal, Quebec · NCT07884539

• Can the Ronnie Gardiner Method improve thinking and daily function in people with Parkinson’s

  In this 10-week program, adults with Parkinson’s disease will try the Ronnie Gardiner Method to see if it helps thinking, talking, movement, balance, and quality of life.

  Recruiting University Ghent · Ghent, Oost-Vlaanderen · NCT07863219

• Beef-Protein Ready-to-Eat Meals to Support Firefighter Recovery

  This study tests whether beef-based ready-to-eat meals help firefighters recover better after simulated firefighting tasks, compared with plant-based meals.

  Recruiting at 2 sites Sam Houston State University · Fort Worth, Texas and 1 other locations · NCT07822048

• How pork protein affects recovery after simulated firefighting

  This study tests whether pork-based meals help firefighters recover better and perform sooner after hard simulated fire drills, compared with plant-based meals or carbohydrate-focused meals.

  Recruiting at 2 sites Sam Houston State University · Fort Worth, Texas and 1 other locations · NCT07819565

• LpD3.5 Intervention for Gut Health and Cognition in Older Adults with MCI

  In older adults with mild cognitive impairment, this study tests whether daily LpD3.5 capsules can improve gut health and potentially cognition compared with placebo.

  Recruiting Early Phase 1 University of South Florida · Tampa, Florida · NCT07794956

• Appetite and Thinking Response to a Breakfast Cereal

  This study tests how eating a ready-to-eat breakfast cereal affects appetite and thinking in healthy adults who regularly eat cereal.

  Recruiting General Mills · Minneapolis, Minnesota · NCT07782229

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.