Comparing point-of-care and laboratory testing for heart attack diagnosis
Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain: a Randomized Study (POC Troponina)
NA · University of Sao Paulo · NCT06861582
This study is testing if a quick bedside test for heart attacks can help patients with chest pain leave the hospital faster than using the traditional lab tests.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Sao Paulo (other) |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT06861582 on ClinicalTrials.gov |
What this trial studies
This clinical study evaluates the effectiveness of point-of-care testing for ultrasensitive troponin I compared to traditional laboratory testing in patients with chest pain suggestive of acute coronary syndromes. It aims to determine whether the point-of-care method can reduce the time from hospital admission to discharge. The study involves randomizing patients into two groups, one receiving point-of-care testing and the other receiving laboratory-based testing, with a focus on measuring the efficiency of care provided by each method. The primary outcome is the length of hospital stay for patients diagnosed with Non-ST Elevation Acute Coronary Syndrome.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who present to the emergency room with chest pain symptoms suggestive of acute coronary syndromes.
Not a fit: Patients with ST-segment elevation on ECG, chronic conditions affecting troponin interpretation, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to faster diagnosis and discharge for patients with chest pain, improving overall patient care and resource utilization in emergency settings.
How similar studies have performed: Previous studies have shown promise in using point-of-care testing for rapid diagnosis in acute coronary syndromes, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥ 18 years. * Patients arriving in the emergency room with symptoms suggestive of ACS, with onset of pain between 3 and 12 hours after arrival, in whom serial troponin dosing is planned for investigation. * Signature of the Informed Consent Form (ICF). Exclusion Criteria: * Patients presenting with ACS with ST-segment elevation on the 12-lead ECG on arrival at hospital. * Patients with conditions that interfere with the interpretation of troponin dosage (chronic renal failure, cancer, chronic lung diseases). * Pregnant or breastfeeding patients. * Patients already included in other clinical research protocols.
Where this trial is running
São Paulo
- Instituto do Coração HCFMUSP — São Paulo, Brazil (RECRUITING)
Study contacts
- Principal investigator: Ludhmila A Hajjar, Professor — University of Sao Paulo
- Study coordinator: José León
- Email: aro@incor.usp.br
- Phone: +55 (11) 2661-5795
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Coronary Syndromes, Troponin I, Point-of-Care Testing, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction, Biomarkers, Emergency Service, Hospital, Myocardial Ischemia