Comparing point-of-care and laboratory testing for heart attack diagnosis
Official title: Effect of Point-of-care Analysis of Ultrasensitive Troponin I on Length of Hospital Stay in Patients With Cardiac Chest Pain: a Randomized Study (POC Troponina)
Run by University of Sao Paulo · NCT06861582 · Data updated 2026-11-12
This study is testing if a quick bedside test for heart attacks can help patients with chest pain leave the hospital faster than using the traditional lab tests.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University of Sao Paulo Academic / other |
| Locations | 1 site (São Paulo) |
| Status | Recruiting |
| Started | March 10, 2025 |
| Main results expected | March 2026 |
| Study ends | March 2026 |
| Registry record updated | April 8, 2025 |
| Trial ID | NCT06861582 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who present to the emergency room with chest pain symptoms suggestive of acute coronary syndromes.
✕Probably not a fit
Patients with ST-segment elevation on ECG, chronic conditions affecting troponin interpretation, or those who are pregnant or breastfeeding may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical study evaluates the effectiveness of point-of-care testing for ultrasensitive troponin I compared to traditional laboratory testing in patients with chest pain suggestive of acute coronary syndromes. It aims to determine whether the point-of-care method can reduce the time from hospital admission to discharge. The study involves randomizing patients into two groups, one receiving point-of-care testing and the other receiving laboratory-based testing, with a focus on measuring the efficiency of care provided by each method. The primary outcome is the length of hospital stay for patients diagnosed with Non-ST Elevation Acute Coronary Syndrome.
Why it matters
Potential benefit: If successful, this approach could lead to faster diagnosis and discharge for patients with chest pain, improving overall patient care and resource utilization in emergency settings.
How similar studies have gone: Previous studies have shown promise in using point-of-care testing for rapid diagnosis in acute coronary syndromes, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged ≥ 18 years. * Patients arriving in the emergency room with symptoms suggestive of ACS, with onset of pain between 3 and 12 hours after arrival, in whom serial troponin dosing is planned for investigation. * Signature of the Informed Consent Form (ICF). Exclusion Criteria: * Patients presenting with ACS with ST-segment elevation on the 12-lead ECG on arrival at hospital. * Patients with conditions that interfere with the interpretation of troponin dosage (chronic renal failure, cancer, chronic lung diseases). * Pregnant or breastfeeding patients. * Patients already included in other clinical research protocols.
Where it's running
-
Instituto do Coração HCFMUSP
São Paulo, Brazil Recruiting
Study contacts
- Principal investigator: Ludhmila A Hajjar, Professor — University of Sao Paulo
- Study coordinator: José León
- Email: aro@incor.usp.br
- Phone: +55 (11) 2661-5795
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.