Single-dose ayahuasca versus esketamine for PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a Phase 2, double-blind, randomized trial comparing a single dose of oral ayahuasca to a single dose of esketamine in people diagnosed with PTSD. Participants are randomly assigned to one of the two interventions and neither participants nor most study staff know which treatment was given. Symptom ratings, safety monitoring, and follow-up visits are used to track response after the dosing session. People with significant psychiatric or medical comorbidities are excluded and all treatments are administered at the Hospital das Clínicas da FMRP-USP in Ribeirão Preto, São Paulo.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* posttraumatic stress disorder

Exclusion Criteria:

* psychiatric and other medical comorbidities

Where it's running

• Hospital das Clínicas da FMRP-USP
  Ribeirão Preto, São Paulo, Brazil Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.