Sponsor or institution
Clinical trials and research at Ohio State University Comprehensive Cancer Center
As of November 12, 2026, Find a Trial lists 107 clinical trials run by Ohio State University Comprehensive Cancer Center that are recruiting, at sites in 3 countries (most in United States (107), Australia (1), Canada (1)). By phase: Phase 2 (30), Phase 1 (15), Phase 1/2 (7), Phase 4 (3). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 107Clinical trials
- 3Countries
Newest trials
All recruiting trials (107)
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Multiomic analysis in relapsed small-cell lung cancer with DLL3 T cell engager
This observational study tests how blood and tumor markers change over time in adults with relapsed small-cell lung cancer who are receiving a DLL3-targeted therapy, to see if those changes relate to clinical outcomes.
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Alternating chemo-immunotherapy and FGFR inhibitor for FGFR-positive biliary tract cancer
This phase 2 trial tests whether alternating gemcitabine/cisplatin with durvalumab and the FGFR2 inhibitor pemigatinib can help people with unresectable or metastatic biliary tract cancers that have FGFR alterations.
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Venetoclax plus Zanubrutinib for CLL/SLL in frontline or previously treated patients
This phase II trial tests if venetoclax plus zanubrutinib can safely and effectively treat adults with chronic lymphocytic leukemia or small lymphocytic lymphoma, including those who are newly diagnosed and those who have had prior therapy.
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DCE-MRI to help plan surgery for borderline resectable pancreatic cancer
This trial tests whether adding DCE-MRI imaging to standard care can better gauge how pancreatic tumors respond to treatment in patients whose cancer might be removable by surgery.
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Navigation program to boost survivorship support participation for non-metastatic breast cancer survivors
This program tests whether a patient navigation service helps non-metastatic breast cancer survivors use survivorship support services more often.
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Abuse liability and use patterns of IQOS heated tobacco among adult smokers
The study tests how appealing and user-friendly IQOS heat sticks are for adults who smoke, and compares how people puff and use IQOS versus their usual cigarettes.
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Pirtobrutinib for Elderly CLL: See if this BTK inhibitor helps older adults
This study tests whether pirtobrutinib can help people aged 75 and older with chronic lymphocytic leukemia that hasn’t been treated yet.
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Lymphodepletion with low-dose whole-body radiation before standard CAR-T therapy for large B-cell lymphoma
This early-phase trial tests if adding low-dose total body irradiation before standard lymphodepletion and tisagenlecleucel CAR-T therapy is safe and helps patients with relapsed or refractory large B-cell lymphoma see better responses.
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Infliximab to Help Prevent CRS During Teclistamab or Talquetamab Therapy in Relapsed/Refractory Myeloma
This phase 2 trial tests whether infliximab can prevent cytokine release syndrome in patients with relapsed or refractory multiple myeloma who are being treated with teclistamab or talquetamab.
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MyCap app to track time burden of pancreatic cancer treatment
This study tests whether a mobile app can help adults with pancreatic cancer log the time they spend on cancer care.
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Cognitive training to help brain function in people getting CAR-T therapy for relapsed or refractory blood cancers
A brain-training program given before and after CAR-T therapy is tested to see if it helps cognitive and neurological outcomes for adults with relapsed or refractory multiple myeloma or B-cell non-Hodgkin lymphoma.
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Nicotine's Effects on Eye Movements in E-Cigarette Users
This study tests how nicotine from e-cigarettes affects eye movements and related behaviors in adults who regularly use nicotine-containing e-cigarettes.
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Comparative evaluation of nicotine analogs for nicotine EC users
This early-stage trial tests whether two nicotine-like compounds (6-MN and nicotinamide) differ from nicotine in how they feel, how much people use them, and how they affect the body in adult e-cigarette users.
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Resiliency and Operative Success for Lung Cancer Surgery: Prehab with In-Person and BeFitMe Options
This trial tests two prehab programs—one in-person and one virtual—to see if pre- and post-surgery physical therapy and relaxation help adults undergoing lung cancer surgery feel steadier and have better recovery.
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Impact of Menthol vs. Non-Menthol Cigarettes on Abuse Liability
This study tests whether menthol cigarettes have different abuse potential than non-menthol cigarettes in menthol cigarette users, using a within-subject design across lab sessions and daily diaries.
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Nemtabrutinib and venetoclax in untreated CLL/SLL
This phase 2 study tests whether combining nemtabrutinib with venetoclax can help people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma.
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Endoscopic chemoablation for pancreatic cysts
This phase 2 trial tests whether injecting chemotherapy into pancreatic cysts using an endoscope can help treat these precancerous lesions in adults who aren’t surgical candidates.
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How nicotine pouches affect users and public health
This study tests different nicotine pouch types and concentrations to see how they feel to users and whether people switch from cigarettes to pouches.
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Body position and bladder hold time during BCG treatment for non-muscle invasive bladder cancer
This project will test whether lying down or sitting during BCG treatment changes how long the medicine stays in the bladder for people with intermediate- or high-risk non-muscle invasive bladder cancer.
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Focused upper-body massage after radiation for people with breast cancer
This pilot will try offering focused upper-body chair massages after radiation to people receiving curative breast cancer radiation to see if it reduces muscle and joint achiness and improves quality of life.
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Tarlatamab treatment for extensive-stage small cell lung cancer
This phase II trial tests tarlatamab, a bispecific antibody, to see if it helps adults with extensive-stage small cell lung cancer live longer and delay tumor growth.
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Vaginal DHEA to improve vaginal health after pelvic radiation
This phase II trial tests whether daily vaginal DHEA can help reduce vaginal dryness, pain, and related symptoms in menopausal women after radiation for gynecologic, anal, or rectal cancers.
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Breathing-muscle training during chemotherapy for early-stage breast cancer
This tests whether breathing exercises using a small hand-held device can strengthen inhalation muscles, reduce shortness of breath, and help activity levels in women receiving chemotherapy for early-stage breast cancer.
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Ruxolitinib maintenance after stem cell transplant for T‑cell lymphoma
This phase II trial tests whether taking ruxolitinib after a stem cell transplant can lower the chance of relapse and graft‑versus‑host disease for people treated for T‑cell lymphoma.
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Graduate students' views and social influences about oral nicotine pouches
We will test whether social-norms and visual risk messages help Ohio State graduate students better understand and share accurate information about the addictive risks of oral nicotine pouches.
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Sleep Changes and Biomarkers After Breast Cancer Treatment
This project will see how sleep patterns and stress-related biological markers change from treatment through survivorship in people with stage I–III hormone receptor–positive breast cancer.
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Tracking risk awareness and improving knowledge about alcohol-related breast cancer in young adult women
This project will test whether co-created digital messages can reduce drinking and increase young women's awareness that alcohol raises breast cancer risk.
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Low-dose post-transplant cyclophosphamide plus tacrolimus and ruxolitinib to prevent GVHD after myeloablative peripheral blood stem cell transplant
This test sees if adding low-dose post-transplant cyclophosphamide with tacrolimus and ruxolitinib can reduce severe acute graft-versus-host disease in adults receiving myeloablative peripheral blood stem cell transplants for leukemia or myelodysplasia.
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Living Well with Advanced Breast Cancer: Understanding Supportive Care Needs
This project asks adults with advanced (stage IV) breast cancer and their caregivers about what supportive care has helped, what’s been hard, and what help they still need.
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Spine tumor registry tracking outcomes after separation surgery and radiation
This registry will collect information to see what outcomes adults with primary or metastatic spine tumors have after separation surgery followed by radiation.
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Viewing your street in virtual reality: original versus digitally altered opposite streetscape
This test shows adult neighborhood residents short virtual reality scenes of either their actual street or a digitally altered ‘opposite’ version to see if those views change stress, emotion, and physiological responses.
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Psilocybin-assisted therapy for major depression in people with non-small cell lung cancer
This phase II trial tests whether a single oral dose of psilocybin combined with psychotherapy can reduce moderate-to-severe depression in adults with non-small cell lung cancer.
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Off-label insurance coverage and care delays for people with advanced skin cancers
This study will see if adults with resectable advanced skin cancers face longer approval times, higher out-of-pocket costs, or different surgical outcomes when given off-label versus on-label neoadjuvant treatments.
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Improving mailed FIT screening in Appalachia
This project will test whether changing the FIT kit materials and using phone versus text message navigation can help more average-risk adults in Appalachian counties complete colorectal cancer screening when they're overdue.
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RYZ101 (225Ac-DOTATATE) for progressive or recurrent intracranial meningioma
This trial tests whether RYZ101, a radiopharmaceutical, can help people with growing or returning brain meningiomas that express somatostatin receptors.
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Probiotic support for gut and vaginal microbiome during platinum chemotherapy for advanced or recurrent ovarian cancer
This trial will test whether taking a probiotic during platinum chemotherapy helps keep the gut and vaginal microbiome healthier and may improve symptoms, quality of life, or cancer outcomes for people with advanced or recurrent ovarian cancer.
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Brief telehealth psychological support during pre-surgery (neoadjuvant) treatment for localized pancreatic cancer
We will try weekly 40-minute telehealth sessions with a psychologist to reduce stress and improve quality of life for people with localized pancreatic cancer receiving neoadjuvant chemotherapy or radiation.
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How menthol and cooling agents change the appeal of oral nicotine pouches
This test checks whether menthol, a synthetic cooling agent (WS-3), or both make oral nicotine pouches more appealing and better at relieving cravings for adult cigarette smokers.
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Nicotine strength and flavor in oral pouches and alcohol use in young adults
This study tests whether different nicotine strengths and flavors in oral nicotine pouches lead 21–30-year-olds to drink more, drink longer, or have different side effects during and after drinking.
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Treatment of recurrent high-grade gliomas using anti-GARP CAR T cell therapy
This study is testing a new type of CAR T cell therapy to see if it can safely help people with recurring high-grade gliomas fight their tumors better.
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Guided meditation to reduce anxiety before cancer surgery
This study tests if listening to a guided meditation can help reduce anxiety in patients getting ready for cancer surgery compared to wearing noise-canceling headphones.
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Ziftomenib for NPM1-mutated or KMT2A-rearranged AML in patients not eligible for standard therapy
This phase 2 trial tests ziftomenib in people with NPM1-mutated or KMT2A-rearranged AML who can’t receive standard treatment to see if it can help them.
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Using pemigatinib to treat advanced pancreatic cancer with FGFR genetic changes
This study is testing if a new drug called pemigatinib can help adults with advanced pancreatic cancer that has specific genetic changes feel better and possibly live longer.
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Oral nicotine pouches versus patches and lozenges to reduce cigarette use in rural Appalachia
This compares oral nicotine pouches with nicotine patches and lozenges to see if they help adults in rural Appalachia who smoke cut down or quit cigarettes.
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Using acalabrutinib to treat chronic lymphocytic leukemia and small lymphocytic lymphoma
This study is testing if acalabrutinib can safely treat people with chronic lymphocytic leukemia or small lymphocytic lymphoma who can't tolerate ibrutinib, while also keeping an eye on their heart health.
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Using Adapted Argentine Tango to Help Breast Cancer Survivors with Neuropathy
This study is testing whether adapted Argentine Tango can help breast cancer survivors with nerve pain from chemotherapy feel better and improve their movement.
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Mobile health intervention to help colorectal cancer survivors and their caregivers follow lifestyle recommendations
This study is testing a new mobile app to help colorectal cancer survivors and their caregivers stick to healthy lifestyle habits through goal-setting and coaching.
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BZLF1 peptide vaccine with QS-21 to prevent EBV-related cancers in patients awaiting organ transplants
This early-phase trial tests a BZLF1-based vaccine (OSU-2131) with QS-21 to see if it is safe and can help prevent EBV infection and related cancers in healthy people and in patients waiting for a solid organ transplant.
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Epcoritamab treatment for relapsed or refractory post-transplant lymphoproliferative disorders
This study is testing a new treatment called epcoritamab to see if it can help people with relapsed or stubborn post-transplant lymphoproliferative disorders feel better.
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Program to increase cancer screening among low-income women in Central Ohio
This study is trying to see if a new program can help low-income women in Central Ohio get better access to cancer screenings for breast, cervical, and colorectal cancers.
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Effects of Low Nicotine Filtered Little Cigars on Smoking Behavior
This study looks at how smoking little cigars with less nicotine affects how often people smoke and their lung health.
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Nutrition intervention for women with triple negative breast cancer
This study is testing if following a healthy eating plan called the MIND diet can help women with triple negative breast cancer feel better mentally and physically while they are undergoing chemotherapy.
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Combination treatment of epcoritamab and ibrutinib for aggressive B-cell lymphoma
This study is testing a new combination of two treatments, epcoritamab and ibrutinib, to see if they can help people with aggressive B-cell lymphoma that hasn't responded to other therapies.
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All-trans retinoic acid (ATRA) plus cemiplimab for advanced leiomyosarcoma
This trial will try combining oral all-trans retinoic acid with the immunotherapy cemiplimab to see if it can shrink tumors or slow progression in adults with metastatic or unresectable leiomyosarcoma after standard chemotherapy.
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Axatilimab with or without azacitidine for adults with advanced myeloproliferative neoplasms or high‑risk CMML
This trial tests whether the antibody axatilimab, alone or together with the chemotherapy azacitidine, can help adults with advanced‑phase myeloproliferative neoplasms, MPN/MDS overlap, or high‑risk chronic myelomonocytic leukemia (CMML).
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Using 68Ga-DOTATATE PET/CT to diagnose soft tissue sarcomas
This study is testing a new type of imaging called 68Ga-DOTATATE PET/CT to see if it can help doctors better diagnose soft tissue sarcomas in patients.
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Using siltuximab to prevent severe side effects during cancer treatment
This study is testing if the drug siltuximab can help prevent severe side effects in cancer patients who are getting immune therapy again.
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Combining pirtobrutinib and venetoclax for treating resistant CLL or SLL
This study is testing if combining two drugs, pirtobrutinib and venetoclax, can help people with chronic lymphocytic leukemia or small lymphocytic lymphoma that hasn’t responded to previous treatments.
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Manipulating nicotine in e-cigarettes to improve public health
This study tests how different amounts and types of nicotine in e-cigarettes can affect addiction and health risks to help find safer options for smokers and young adults.
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Bowel management program for treating low anterior resection syndrome in rectal cancer patients
This study is testing a bowel management program using special enemas to see if it helps people with low anterior resection syndrome after rectal cancer surgery feel better compared to standard treatment.
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Comparing the effects of relugolix and leuprolide on heart health in prostate cancer patients
This study is testing whether relugolix or leuprolide is better for heart health in men with prostate cancer who are also getting radiation treatment.
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Lower dose radiation therapy guided by blood tests for HPV-related throat cancer
This study is testing if using blood tests to guide lower doses of radiation therapy can help people with HPV-related throat cancer do better than the usual treatment.
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Evaluating oral nicotine pouches as a safer alternative to tobacco products
This study tests if using oral nicotine pouches can be a safer alternative for people trying to quit cigarettes and smokeless tobacco.
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Connecting underrepresented populations to clinical trials at Ohio State University
This study is trying to find better ways to connect racial and ethnic minorities to cancer clinical trials at Ohio State University to help them participate more.
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Combining futibatinib and durvalumab before bladder cancer surgery for patients who can't use cisplatin
This study is testing if combining two drugs, futibatinib and durvalumab, before bladder cancer surgery can help patients who can't take cisplatin feel better and improve their chances of recovery.
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Comparing tobacco-flavored and non-tobacco flavored e-cigarettes for smoking cessation
This study tests whether tobacco-flavored e-cigarettes, non-tobacco flavored e-cigarettes, or nicotine replacement therapy can help current smokers quit smoking and manage their cravings better.
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Effects of tobacco cut and nicotine form on addiction potential of moist snuff
This study tests how different types of moist snuff affect addiction levels in Appalachian teens and adults who use it.
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Using EMLA cream to reduce pain during lymphoscintigraphy for skin cancer
This study is testing if EMLA cream can help reduce pain for patients getting injections during a lymphoscintigraphy procedure for skin cancer.
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Combination treatment for relapsed or refractory acute myeloid leukemia with specific mutations
This study is testing a new combination of two drugs for people with relapsed or hard-to-treat acute myeloid leukemia that has specific gene mutations to see if it helps them feel better.
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Combining CC-99282 with Rituximab for Non-Hodgkin's Lymphoma Treatment
This study is testing a new combination of a pill called CC-99282 and an infusion called rituximab to see if it helps people with non-Hodgkin's lymphoma who didn't respond well to previous treatments.
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Effects of nicotine product claims on perceptions and behavior
This study tests how different claims about nicotine in oral nicotine pouches affect how young adults and tobacco users think and act towards these products.
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Using weighted blankets to reduce anxiety in cancer patients during infusions
This study is testing whether using weighted blankets can help reduce anxiety in cancer patients during their first infusion therapy.
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Gemcitabine and NK cells with or without Naxitamab for metastatic HER2-negative breast cancer
This study is testing a new treatment using gemcitabine and special immune cells, with or without naxitamab, to see if it helps people with advanced HER2-negative breast cancer feel better and live longer.
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Diet intervention to support brain health in women with breast cancer
This study is testing if following the MIND diet can help women with hormone receptor-positive breast cancer feel better mentally while they are receiving treatment.
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Endoscopic ultrasound-guided radiofrequency ablation for pancreatic tumors
This study is testing a new, less invasive treatment using ultrasound and heat to see if it can safely help people with pancreatic tumors, especially cystic neoplasms.
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Combining zanubrutinib and CAR T-cell therapy for treating Richter's syndrome
This study is testing if combining zanubrutinib with CAR T-cell therapy can help people with Richter's syndrome, which is when chronic lymphocytic leukemia turns into a more aggressive lymphoma.
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Combination treatment of tafasitamab and rituximab for post-transplant lymphoma
This study is testing if a combination of two medications, tafasitamab and rituximab, can effectively treat lymphoma that develops after organ transplants.
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Tegavivint treatment for patients with relapsed or refractory large B-cell lymphoma
This study is testing a new treatment called tegavivint to see if it can help people with relapsed or refractory large B-cell lymphoma feel better and how much of the drug is safe to use.
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Biobehavioral stress reduction for patients with triple negative breast cancer
This study is testing a stress reduction program for people who have just been diagnosed with triple negative breast cancer to see if it helps them feel better and cope with their situation.
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Using canakinumab to prevent cancer in patients with low blood cell counts
This study is testing if the drug canakinumab can help prevent cancer in people with low blood cell counts and certain genetic changes.
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Using ruxolitinib to treat T-cell large granular lymphocytic leukemia
This study is testing if the medication ruxolitinib can help shrink tumors in people with T-cell large granular lymphocytic leukemia and improve their quality of life.
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Natural Killer Cell Therapy and Temozolomide for Stage IV Melanoma with Brain Metastasis
This study is testing a new treatment combining special immune cells and a cancer drug to see if it helps people with advanced melanoma that has spread to the brain.
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Genetically engineered CAR T-cells for treating certain blood cancers
This study is testing a new type of treatment using specially modified immune cells to see if they can help people with certain blood cancers that haven't responded to other treatments.
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Using minoxidil to treat hair loss in breast cancer patients on endocrine therapy
This study is testing if a hair loss treatment called minoxidil, given either as a foam or a pill, can help women with breast cancer who are losing their hair due to cancer therapy.
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Vaccination strategy for patients with chronic lymphocytic leukemia
This study is testing a new vaccination schedule to see if it helps people with chronic lymphocytic leukemia better fight off infections compared to the usual vaccination plan.
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Comparing treatment sequences for older patients with IDH mutated acute myeloid leukemia
This study is testing which order of treatments works better for older patients with a specific type of leukemia that can't handle intensive therapy, by comparing an IDH inhibitor with venetoclax, both combined with azacitidine.
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Acalabrutinib combined with venetoclax or obinutuzumab for treating chronic lymphocytic leukemia
This study is testing if a new combination of two drugs, acalabrutinib with either venetoclax or obinutuzumab, can help people with chronic lymphocytic leukemia who haven't been treated before by reducing cancer cells in their bone marrow.
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Combining PBF-1129 and Nivolumab for Advanced Lung Cancer Treatment
This study is testing a new combination of two drugs, PBF-1129 and nivolumab, to see if it can help people with advanced lung cancer live longer and feel better.
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Evaluating how diet affects breast cancer risk
This study is trying to see if the way women eat affects their risk of getting breast cancer, especially for those who are already at high risk.
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Combining vertebroplasty and radiation therapy for spine cancer patients
This study is testing whether combining a special type of radiation therapy with a procedure to strengthen the spine can help people with tough-to-treat cancer in that area feel better and live longer.
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Using papaverine with chemoradiation to treat advanced non-small cell lung cancer
This study is testing the best dose of papaverine combined with chemotherapy and radiation to see if it helps people with advanced non-small cell lung cancer live longer and control their tumors better.
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Using natural killer cells and mogamulizumab to treat relapsed or refractory cutaneous T-cell lymphomas and adult T-cell leukemia/lymphoma
This study is testing a new treatment using natural killer cells and mogamulizumab to see if it helps people with tough-to-treat skin lymphomas and adult T-cell leukemia feel better and live longer.
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Combining osimertinib and tegavivint for treating metastatic EGFR-mutant lung cancer
This study is testing a new combination of two drugs, osimertinib and tegavivint, to see if it can help people with advanced lung cancer caused by EGFR mutations feel better and live longer.
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Combining immunotherapy and radiation for recurrent head and neck cancer
This study is testing if combining a new immune treatment with radiation can help people with recurrent head and neck cancer feel better and live longer.
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Using an influenza vaccine to treat melanoma
This study is testing whether an influenza vaccine can safely help people with melanoma, a type of skin cancer, by seeing how well it works to shrink tumors and improve their condition.
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Collecting and storing tissue samples from melanoma patients
This study is collecting blood and tumor samples from melanoma patients and healthy people to help researchers learn more about melanoma and find better ways to treat it.
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Using Vyxeos to treat acute myeloid leukemia patients with persistent disease after initial chemotherapy
This study is testing if a new treatment called Vyxeos can help people with acute myeloid leukemia who didn't get better with standard chemotherapy.
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Examining immune cell function in breast cancer patients
This study looks at how certain immune cells work in people with breast cancer to see if it can help find better treatments in the future.
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High-resolution imaging to detect micrometer-scale cancer in pancreatic tissue
This study tests ultra-high resolution optical coherence tomography (OCT) to see if it can spot tiny cancer cells in pancreatic tissue from people having pancreatic surgery for IPMN or pancreatic cancer.
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Donor-derived virus-specific T cell therapy for CMV or adenovirus after organ or stem-cell transplant
This tests donor-derived virus-specific T cells to treat CMV or adenovirus reactivation in people who have had a solid organ or stem-cell transplant.
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Using confocal laser endomicroscopy to diagnose pancreatic cysts
This study is testing a new imaging technique to see if it can help doctors better diagnose pancreatic cysts in patients who are already being checked for these issues.
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Improving survival in patients with advanced lung cancer in Ohio
This study is testing a new approach to help people with advanced lung cancer in Ohio live longer and feel better by using advanced genetic and immune system tests to guide their treatment.
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Registry for patients with bone and soft tissue tumors
This study is creating a secure online registry to collect health information from people with bone and soft tissue tumors to help improve treatment and understand their condition better.
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Registry for patients with hairy cell leukemia
This study is collecting information from people with hairy cell leukemia to help find better treatments and improve their quality of life.
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Precision cancer medicine using high-throughput sequencing for advanced cancer
This study is collecting tumor samples from patients with advanced cancer to see if their genetic information can help find better treatment options in the future.
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Using robotic surgery to treat tumors in the head and neck
This study is testing if using robotic surgery to remove tumors in the mouth and throat can help patients recover faster and feel better afterwards.
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Registry and sample resource for patients with plasma cell disorders
This study is gathering information from patients with plasma cell disorders like multiple myeloma to see how to improve their treatment and quality of life.
Quick answers
How many clinical trials run by Ohio State University Comprehensive Cancer Center are recruiting right now?
107, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (107 trials), Australia (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 30, Phase 1: 15, Phase 1/2: 7, Phase 4: 3. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.