Effects of tobacco cut and nicotine form on addiction potential of moist snuff
Official title: Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
Run by Ohio State University Comprehensive Cancer Center · NCT06249984 · Data updated 2026-11-12
This study tests how different types of moist snuff affect addiction levels in Appalachian teens and adults who use it.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Ohio State University Comprehensive Cancer Center Academic / other |
| Locations | 2 sites (Columbus, Ohio and 1 other locations) |
| Status | Recruiting |
| Started | December 20, 2024 |
| Main results expected | March 1, 2027 |
| Study ends | January 31, 2028 |
| Registry record updated | August 17, 2026 |
| Trial ID | NCT06249984 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include Appalachian adolescents and adults who are current users of moist snuff or dual users of combustible tobacco products.
✕Probably not a fit
Patients who do not use moist snuff or are not residents of the participating Appalachian counties may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates how different characteristics of moist snuff, specifically the length of tobacco cut and the form of nicotine, influence addiction potential among users. Participants will engage in five study visits where they will use various types of moist snuff while undergoing blood sample collection and carbon monoxide testing. The study aims to assess the relationship between these product features and the level of dependence in Appalachian adolescents and adults. The findings may inform regulations to reduce the appeal and addictiveness of moist snuff products.
Why it matters
Potential benefit: If successful, this study could lead to better regulations that reduce the addictive potential of moist snuff, ultimately benefiting public health.
How similar studies have gone: While there have been studies on tobacco addiction, this specific approach focusing on moist snuff characteristics is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project * Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week. * Age 21 years or older * Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification * Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits * Willing to abstain from nicotine and tobacco products 12-hours before study visit * Ability to read and speak English Exclusion Criteria: * Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months * Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months * Severe periodontal or oral lesions
Where it's running
-
Center for Tobacco Research
Columbus, Ohio, United States Recruiting -
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States Not yet recruiting
Study contacts
- Principal investigator: Brittney L Keller-Hamilton, PhD, MPH — Ohio State University Comprehensive Cancer Center
- Study coordinator: The Ohio State Comprehensive Cancer Center
- Email: OSUCCCClinicaltrials@osumc.edu
- Phone: 800-293-5066
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.