Effects of tobacco cut and nicotine form on addiction potential of moist snuff
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
This study tests how different types of moist snuff affect addiction levels in Appalachian teens and adults who use it.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Ohio State University Comprehensive Cancer Center Academic / other |
| Locations | 2 sites (Columbus, Ohio and 1 other locations) |
| Trial ID | NCT06249984 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates how different characteristics of moist snuff, specifically the length of tobacco cut and the form of nicotine, influence addiction potential among users. Participants will engage in five study visits where they will use various types of moist snuff while undergoing blood sample collection and carbon monoxide testing. The study aims to assess the relationship between these product features and the level of dependence in Appalachian adolescents and adults. The findings may inform regulations to reduce the appeal and addictiveness of moist snuff products.
Who should consider this trial
Good fit: Ideal candidates include Appalachian adolescents and adults who are current users of moist snuff or dual users of combustible tobacco products.
Not a fit: Patients who do not use moist snuff or are not residents of the participating Appalachian counties may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better regulations that reduce the addictive potential of moist snuff, ultimately benefiting public health.
How similar studies have performed: While there have been studies on tobacco addiction, this specific approach focusing on moist snuff characteristics is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * AIM 1 (Adults Tobacco User Adult Cohort \[TUAC\]): Exclusive adult smokers who smoked \>100 cigarettes or other combustible tobacco products in their lifetime and reported being current, every day, or some days/week smokers at time of enrollment * AIM 1 (TUAC): Exclusive SLT user reporting every day or some days use per week at time of enrollment * AIM 1 (TUAC): Or dual users who met criteria for both aims at time of enrollment who resided in participating Appalachian and urban counties * AIM 1 (Buckeye Teen Health Study \[BTHS\]): Male youth ages 12-15 in Appalachian and urban regions of Ohio with parental consent and participant assent given * AIM 2: As derived from Aim 1, commercially available SLT products used by TUAC and BTHS participants will be purchased from retailers in nearby Appalachian counties, as composition of SLT products can vary regionally * AIM 3: Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project * Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week. * Age 21 years or older * Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification * Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits * Willing to abstain from nicotine and tobacco products 12-hours before study visit * Ability to read and speak English Exclusion Criteria: * Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months * Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months * Severe periodontal or oral lesions
Where this trial is running
Columbus, Ohio and 1 other locations
- Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States (Not_yet_recruiting)
- Center for Tobacco Research — Columbus, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Brittney L Keller-Hamilton, PhD, MPH — Ohio State University Comprehensive Cancer Center
- Study coordinator: The Ohio State Comprehensive Cancer Center
- Email: OSUCCCClinicaltrials@osumc.edu
- Phone: 800-293-5066
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.