Using minoxidil to treat hair loss in breast cancer patients on endocrine therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This early phase I trial investigates the effects of topical and oral minoxidil on hair loss caused by endocrine therapy in women with stage I-IV breast cancer. The study aims to evaluate the safety and tolerability of low-dose oral minoxidil and to gather preliminary data on its effectiveness compared to topical minoxidil. Participants will be randomized into two groups: one applying minoxidil foam topically and the other receiving it orally, both for up to 12 months. The trial focuses on improving quality of life by addressing the distressing side effect of hair loss during cancer treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women \>= 18 years of age
* Established diagnosis of breast cancer stages I-IV
* On endocrine therapy including tamoxifen or aromatase inhibitors with or without concurrent use of ovarian function suppression
* Self-reporting hair loss since starting endocrine therapy

Exclusion Criteria:

* Pregnant or nursing women
* Current chemotherapy use or prior chemotherapy use within the last 2 years
* History of scarring/cicatricial alopecia or alopecia areata
* Prior use of oral or topical minoxidil
* Prior or ongoing use of spironolactone
* Known sensitivity to minoxidil
* Untreated hypothyroidism or iron deficiency as determined by thyroid stimulating hormone (TSH) with reflex free T4 and ferritin level \> 40 to be checked at the time of enrolling if not completed in the 12 months prior

Where it's running

• Ohio State University Comprehensive Cancer Center
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Brittany L Dulmage, MD — Ohio State University Comprehensive Cancer Center
• Study coordinator: The Ohio State University Comprehensive Cancer Center
• Email: OSUCCCClinicaltrials@osumc.edu
• Phone: 800-293-5066

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.