Spine tumor registry tracking outcomes after separation surgery and radiation
Official title: A Prospective Registry of Patients Undergoing Surgical Decompression Followed by Radiation Therapy for Spine Tumors
Run by Ohio State University Comprehensive Cancer Center · NCT07225491 · Data updated 2026-11-12
This registry will collect information to see what outcomes adults with primary or metastatic spine tumors have after separation surgery followed by radiation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | Ohio State University Comprehensive Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 5 sites (Indianapolis, Indiana and 4 other locations) |
| Status | Recruiting |
| Started | November 24, 2025 |
| Main results expected | December 31, 2035 |
| Study ends | December 31, 2037 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT07225491 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with primary or metastatic disease to the spine who undergo surgical decompression and stabilization followed by radiation treatment and who can undergo standard MRI or CT-based planning are the ideal candidates.
✕Probably not a fit
Children, patients who will not receive radiation or cannot undergo standard MRI/CT planning, and people not having separation surgery are unlikely to benefit from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry collects clinical data and patient-reported outcomes from adults with primary or metastatic spine tumors who undergo separation surgery followed by postoperative radiation. Investigators will extract operative details, hardware status, imaging and radiation dosimetry, oncologic outcomes, and adverse events from medical records. Participants will complete standardized questionnaires on pain, function, and quality of life over time. The multi-center design across academic sites aims to describe hardware-related complications and local tumor control without assigning experimental treatments.
Why it matters
Potential benefit: If successful, the registry could help surgeons and radiation teams choose surgical and implant strategies and radiation plans that reduce hardware failures and improve local tumor control and patient-reported outcomes.
How similar studies have gone: Previous observational series and registries of separation surgery followed by stereotactic or conventional radiation have reported useful data on hardware complication rates and local control, so this approach builds on existing, partly successful evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of primary or metastatic disease to the spine who undergo surgical decompression and stabilization followed by radiation therapy Exclusion Criteria: * Inability to obtain a standard MRI or CT / CT myelogram for radiation treatment planning and dosimetry * Inability to receive radiation treatment. * Patients under 18 years of age
Where it's running
-
Indiana University
Indianapolis, Indiana, United States Recruiting -
University of Maryland,
Baltimore, Maryland, United States Recruiting -
University of Michigan
Ann Arbor, Michigan, United States Recruiting -
Rutgers Robert wood Johnson Medical School
New Brunswick, New Jersey, United States Recruiting -
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States Recruiting
Study contacts
- Principal investigator: James B Elder, MD — Ohio State University
- Study coordinator: Courtney Wright
- Email: Courtney.Wright@osumc.edu
- Phone: 614-293-4876
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.