Resiliency and Operative Success for Lung Cancer Surgery: Prehab with In-Person and BeFitMe Options

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores two perioperative programs for adults with potentially resectable non-small cell lung cancer: an in-person plus at-home physical therapy and a virtual BeFitMe option. The primary goal is to determine feasibility, measured by adherence and retention to the interventions. Exploratory analyses will look at gut microbiome diversity and T cell senescence as potential biomarkers of treatment-related toxicity and tumor response, alongside surgical outcomes and survival. Participants choose their arm based on availability, and the programs span before and after surgery with structured exercise and relaxation components. Biospecimen collection and internet-based components are included as part of the interventions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosed with: potentially resectable non small cell lung cancer (NSCLC) stage (9th edition: IB-IIIB)
* Intent to receive surgery following neoadjuvant systemic therapy from the Ohio State University Comprehensive Cancer Center (OSUCCC) Thoracic Oncology Clinic
* Patients who are at least 6 weeks out of the surgery date are eligible to participate
* Willingness to participate and adhere to the study intervention program
* Ability to understand and willingness to sign an informed consent document

Exclusion Criteria:

* Prisoners are excluded from participation
* There is NO exclusion criteria pertaining to Eastern Cooperative Oncology Group (ECOG) performance status, laboratory values, or prior cancer diagnoses
* Patients already enrolled on a therapeutic clinical trial will be excluded from this study as to not confound any exploratory outcomes associated with this trial and/or any clinical trials evaluating novel anti-cancer therapies unless granted permission by the local site principal investigator (PI)

Where it's running

• Ohio State University Comprehensive Cancer Center
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Carolyn J Presley, MD — Ohio State University Comprehensive Cancer Center
• Study coordinator: The Ohio State University Comprehensive Cancer Center
• Email: OSUCCCClinicaltrials@osumc.edu
• Phone: 800-293-5066

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.