Abuse liability and use patterns of IQOS heated tobacco among adult smokers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, two-arm laboratory study compares IQOS heated tobacco products to a usual brand cigarette in adults who smoke. Participants alternate 60-minute sessions using IQOS or their usual cigarette, depending on arm, to assess sensory effects and puffing behavior. Secondary aims explore how flavor and perceived harm influence use, and an exploratory objective looks at acute changes in pulmonary health after IQOS use. The trial is conducted at the Ohio State University Comprehensive Cancer Center with collaboration from the NCI, and includes English-speaking adults 21–65 who smoke regularly. Ad lib use is permitted during laboratory sessions, with abstinence required 12 hours before visits.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults 21-65 years
* Adults who smoke (defined as ≥ 5 days weekly use of either menthol or non-menthol cigarettes over the past 3 months)
* Willing to provide informed consent and abstain from using nicotine products 12 hours before each visit
* Willing to bring UBC to each study visit
* Read, write and speak English

Exclusion Criteria:

* Current use of other non-combustible nicotine products (e.g., electronic \[e\]-cigarettes, HTPs; \[defined as ≥ 5 days weekly use in the past 30 days\])
* Planning to quit nicotine use and/or use of any smoking cessation medication in the past 30 days
* Current diagnosis of any lung diseases (e.g., asthma, cystic fibrosis, or chronic obstructive pulmonary disease)
* Self-reported unstable or significant psychiatric conditions (past/stable conditions will be allowed)
* History of cardiac event or distress within the past 3 months
* Deaf, hard of hearing, or have a severe motor disability
* Are currently pregnant, planning to become pregnant, or breastfeeding (urine pregnancy test will be completed at each visit throughout the study)

Where it's running

• Ohio State University Comprehensive Cancer Center
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Alayna P Tackett, PhD — Ohio State University Comprehensive Cancer Center
• Study coordinator: The Ohio State University Comprehensive Cancer Center
• Email: OSUCCCClinicaltrials@osumc.edu
• Phone: 800-293-5066

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.