High-resolution imaging to detect micrometer-scale cancer in pancreatic tissue
Official title: Imaging and Detection of Micrometer Sized Early Stage Pancreatic Cancer by Using Endoscopic Ultra-High Resolution Optical Coherence Tomography (OCT) Using Resected Pancreatic Specimen, a Pilot Study
Run by Ohio State University Comprehensive Cancer Center · NCT03711890 · Data updated 2026-11-12
This study tests ultra-high resolution optical coherence tomography (OCT) to see if it can spot tiny cancer cells in pancreatic tissue from people having pancreatic surgery for IPMN or pancreatic cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 75 (estimated) |
| Sponsor | Ohio State University Comprehensive Cancer Center Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Status | Recruiting |
| Started | March 26, 2019 |
| Main results expected | September 15, 2026 |
| Study ends | September 15, 2026 |
| Registry record updated | June 15, 2026 |
| Trial ID | NCT03711890 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing pancreatic resection for presumed IPMN or pancreatic cancer at the Ohio State University Comprehensive Cancer Center.
✕Probably not a fit
Patients whose cancer is not detectable by OCT or who do not undergo resection may not receive benefit from this imaging approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial evaluates whether ultra-high resolution OCT can diagnose pancreatic cancer within resected specimens from patients with IPMN or pancreatic cancer. OCT images will be compared with standard histology to see how well OCT detects invasive cancer in the pancreatic duct. The imaging is performed on the surgical specimen and does not alter the tissue prior to pathology. Findings may guide future in vivo uses of OCT to identify early-stage pancreatic cancer during procedures. The study is conducted at Ohio State University Comprehensive Cancer Center and involves adults undergoing planned pancreatic resection.
Why it matters
Potential benefit: If successful, OCT could help pathologists identify invasive cancer more quickly and accurately in surgical specimens.
How similar studies have gone: Previous work with OCT in pancreatic tissue is exploratory; this study builds on to determine diagnostic accuracy in resected specimens.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Immediate surgery cohort: Adult patients with pancreatic cancer or IPMN * Immediate surgery cohort: Informed consent will be obtained * Adult patients undergoing pancreatic resection for a presumed IPMN Exclusion Criteria: * Pregnant
Where it's running
-
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States Recruiting
Study contacts
- Principal investigator: Mary Dillhoff, MD — Ohio State University Comprehensive Cancer Center
- Study coordinator: Ohio State University Comprehensive Cancer Center
- Email: OSUCCCClinicaltrials@osumc.edu
- Phone: 800-293-5066
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.