Manipulating nicotine in e-cigarettes to improve public health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates how different nicotine concentrations and forms in e-cigarettes affect addiction potential and health risks. Participants will engage in multiple vaping sessions using various e-liquid combinations to assess their pharmacological, metabolic, and behavioral responses. The study aims to identify optimal nicotine levels that minimize appeal to young adult users while still attracting smokers. Additionally, toxicity assessments will be conducted to understand the health implications of these nicotine variations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Current exclusive young adult EC user for at least the past 3 months (confirmed by cotinine testing strip) between 21-24 years old with no/minimal history of smoking cigarettes (≤ 10 cigarettes in entire life)
* Current older adult smoker (daily use, ≥ 100 cigarettes in entire life) aged 25-65 with interest in trying an EC
* Willing to abstain from all nicotine, tobacco products, and marijuana for at least 12 hours for Study 1 and 2 hours for Study 2 before study visits
* Read, write, and speak English

Exclusion Criteria:

* Currently attempting to quit nicotine or tobacco products
* Currently pregnant (will be verified with urine pregnancy test), planning to become pregnant, or breastfeeding
* If age 21-24 years old AND use of any tobacco products other than ECs (use of \>10 cigarettes in entire life; use of \>10 traditional cigars, cigarillos, or filtered cigars in entire life; use of smokeless tobacco products \>10 times in entire life; or hookah in the last 30 days).
* Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease
* New or unstable cardiovascular disease diagnosed within the past 3 months
* Use of medications that are inducers of CYP2A6 enzyme such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsion drugs

Where it's running

• Ohio State University Comprehensive Cancer Center
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Theodore L Wagener — Ohio State University Comprehensive Cancer Center

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Smoke-free home program for tribal communities

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.