Clinical trial Recruiting at 1 site Observational

Collecting and storing tissue samples from melanoma patients

Official title: Analysis of the Tumor Microenvironment and Immune Response in Malignant Melanoma

Run by Ohio State University Comprehensive Cancer Center · NCT04567706 · Data updated 2026-11-12

This study is collecting blood and tumor samples from melanoma patients and healthy people to help researchers learn more about melanoma and find better ways to treat it.

Quick facts

Study typeObservational
SexAll
Enrollment1000 (estimated)
SponsorOhio State University Comprehensive Cancer Center
Academic / other
Drugs / interventionschemotherapy, immunotherapy, radiation
Locations1 site (Columbus, Ohio)
StatusRecruiting
StartedMay 7, 2013
Main results expectedOctober 31, 2027
Study endsOctober 31, 2027
Registry record updatedFebruary 17, 2026
Trial IDNCT04567706 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with malignant melanoma at any stage and healthy individuals willing to participate.

Probably not a fit

Patients who are incarcerated will not benefit from this study as they are excluded from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study collects and stores blood and tumor samples from patients diagnosed with malignant melanoma, as well as healthy individuals, to better understand the causes and behavior of melanoma tumors. The primary objective is to facilitate research aimed at identifying new prognostic markers and potential therapeutic options for melanoma. Blood samples will be collected at various stages of the patient's treatment and follow-up, while tissue samples may be obtained during standard medical procedures. This biorepository aims to support future research that could lead to advancements in melanoma diagnosis and treatment.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic and treatment options for patients with malignant melanoma.

How similar studies have gone: Other studies collecting biospecimens for melanoma research have shown promise in identifying new treatment strategies and prognostic markers.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient with malignant melanoma or personal history of melanoma
* Normal donors
* Informed consent can be obtained
* Patients with any stage of malignant melanoma

Exclusion Criteria:

* Incarcerated individuals will be excluded from this protocol

Where it's running

  • Ohio State University Comprehensive Cancer Center
    Columbus, Ohio, United States
    Recruiting

Study contacts

  • Principal investigator: William E Carson, MD — Ohio State University Comprehensive Cancer Center
  • Study coordinator: The Ohio State University Comprehensive Cancer Center
  • Email: OSUCCCClinicaltrials@osumc.edu
  • Phone: 800-293-5066

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Melanoma treatment with immunotherapy guided by serial ctDNA testing

    This trial tests whether regular ctDNA blood tests during treatment can help tailor the plan for patients with advanced melanoma receiving nivolumab and ipilimumab.

    Recruiting Phase 2 H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT07930182

  • Non-invasive skin-tape test to detect melanoma using methylation biomarkers

    A non-invasive skin-tape test is being tried to see if it can detect melanoma in people who are about to have a biopsy for a suspicious pigmented lesion.

    Recruiting at 4 sites Mitra Bio · Ghent and 4 other locations · NCT07883954

  • SI-B036 safety test in advanced and metastatic solid tumors

    This early-phase study checks whether SI-B036 is safe and tolerable in adults with advanced or metastatic solid cancers who have had prior therapy.

    Recruiting at 4 sites Phase 1 SystImmune Inc. · New Haven, Connecticut and 6 other locations · NCT07857616

  • BL-M08D treatment in melanoma and other solid tumors

    A phase Ib/II study tests BL-M08D1 injections in adults with locally advanced or metastatic melanoma and other solid tumors to see if it is safe and helpful.

    Recruiting Phase 1/2 Sichuan Baili Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality · NCT07841925

  • Aggressive lipid lowering in melanoma patients starting immune checkpoint therapy

    This trial tests whether lowering cholesterol aggressively can reduce heart artery disease risk in melanoma patients who are just beginning immune checkpoint therapy.

    Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07704918

  • Timing of Immunotherapy in Melanoma

    This trial tests whether starting standard melanoma immunotherapy earlier in the day (before 10 am) versus later in the day (after 1 pm) makes a difference for patients with unresectable or metastatic melanoma.

    Recruiting Radboud University Medical Center · Amsterdam and 4 other locations · NCT07696715

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.