Condition

Substance Use Disorder clinical trials and research

• 11Clinical trials
• 84NIH research projects
• 2Countries

Newest Substance Use Disorder clinical trials

All recruiting trials (11)

• Honest, Open, Proud for justice-involved veterans

  This trial tests a peer-delivered stigma-reduction program for veterans with co-occurring mental health or substance use disorders who are involved with the justice system, to see if different delivery intensities help more veterans engage in care.

  Recruiting VA Office of Research and Development · Bedford, Massachusetts · NCT07742722

• Olfactory function and decision-making in people with HIV and/or substance use

  This study tests how the sense of smell relates to decision-making in adults with HIV, substance use, both, or neither.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT07637669

• Psychosocial factors linked to outcomes in people with dual diagnosis in a hospital

  This study tests how psychosocial protective factors relate to clinical and functional outcomes in adults hospitalized with both a mental health disorder and substance use disorder.

  Recruiting Hospital Virgen del Puerto · Plasencia, Caceres · NCT07443033

• Digital support to reduce self-stigma for pregnant and postpartum women with substance use disorder

  This project will test whether a smartphone program called Enhearten can reduce self‑stigma and help pregnant and postpartum women with substance use disorder stay in treatment and improve recovery.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07211867

• Mothering from the Inside Out (MIO) for mothers in recovery from substance use

  This will test whether the Mothering from the Inside Out (MIO) parenting program helps mothers in outpatient treatment for substance use disorder improve parenting and support recovery.

  Recruiting Baystate Medical Center · Springfield, Massachusetts · NCT07168642

• Personalized PATH plan for healthier use and recovery

  This project will try giving Veterans with substance use disorder a personal model of what causes their urges and substance use plus a one-hour feedback session to see if that helps their symptoms and recovery.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06580457

• Screening and evaluation for substance use disorders at NIDA

  This study is trying to see if people with and without substance use disorders can join future research at NIDA to help understand drug use and improve treatments.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT06552741

• Helping Veterans quit smoking during cancer care

  This study is testing a new program to help Veterans quit smoking while they are being screened or treated for lung cancer.

  Recruiting VA Office of Research and Development · San Francisco, California · NCT06432985

• Understanding how nicotine affects depression and brain function

  This study is testing how nicotine affects brain function and depression in people with and without major depressive disorder.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT05538910

• PAP treatment for veterans with PTSD and substance use disorder

  This study tests if using a breathing device for sleep apnea can help veterans with PTSD and substance use issues stick to their treatment and feel better.

  Recruiting VA Office of Research and Development · San Diego, California · NCT05156112

• Reentry tools to help Veterans transition successfully after prison

  This project will test a reentry program and brief assessment tools to help veterans with mental illness or substance use disorder who were recently released from prison reconnect to care and succeed in the community.

  Recruiting VA Office of Research and Development · Dallas, Texas · NCT04366531

NIH-funded research (newest 40 of 84)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Co-treated care for substance use and heart infection at UVMMC

  A hospital-based project aims to improve how doctors and teams treat people with both substance use disorder and infective endocarditis during their hospital stay.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11599499

• Genetics study of methamphetamine use disorder in Thai people

  A genetics study in Thailand is looking at how genes may influence methamphetamine use disorder and related behaviors.

  NIH research Yale University · New Haven, United States · NIH-11535768

• PROTECT-ED: Rapid care connects people just released from jail to HIV and overdose prevention

  A program in the emergency department helps people who just left jail get started on medications for opioid use disorder and HIV prevention right away and connect them to ongoing care.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11469759

• Justice Core: Helping pregnant women with substance use get treatment while in jail

  A pragmatic trial will test whether a jail diversion program (Justice Core) improves access to treatment and perinatal outcomes for pregnant women with substance use issues compared to usual referral after jail release.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11449160

• Adapting with Proactive SUD Intervention via Disease Intervention Specialists

  A new program uses a proven outreach model to identify and connect people with substance use disorder to care earlier, by applying DIS tactics to SUD in communities.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11422103

• ED-based Screening and Brief Intervention to Prevent Substance Use Disorder

  A Purdue-led project will test if ED-based screening plus a brief in-person motivational talk and follow-up telehealth coaching can reduce risky substance use and prevent future disorder in diverse adults.

  NIH research Purdue University · West Lafayette, United States · NIH-11422014

• Connecting Primary Care to SUD Treatment with Telehealth Collaborative Care

  A Mayo Clinic study tests a telehealth-based collaborative care platform to help primary care clinics identify and treat substance use disorders in rural adults.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11421130

• Decoding peptidergic programming of the dopamine epigenome in substance use disorder

  Aims to understand how peptide signals change dopamine-related brain changes that contribute to substance use disorder and why this makes treating the condition hard.

  NIH research Northwestern University · Chicago, United States · NIH-11420831

• The impact of peer support on treatment engagement for Medicaid patients with substance use disorder

  A patient-friendly look at how peer support might help adults on Medicaid stay in treatment for substance use disorder and reduce adverse events.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11408816

• Multimodal profiling of HIV and inflammation in brain immune cells

  This project studies how cocaine use and HIV infection affect immune cells in the brain, to find new ways to improve treatments and protect brain health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11408757

• Automated screening of how moms respond to infant distress using wearables to prevent substance use problems

  A caregiver-friendly project using wearables to understand and support how mothers react to their babies’ distress to reduce future risk of substance use disorders.

  NIH research University of Texas at Austin · Austin, United States · NIH-11397027

• Weighting real-world data to understand opioid tapering outcomes in people with chronic pain and substance use disorders

  A real-world study will create and test statistical weights to better understand how tapering opioids works for patients who have chronic pain and substance use disorders.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11394597

• ABC-SUD: Help getting substance use treatment easier for people who need it

  This grant tests a care-navigation program to help people with substance use disorder start and stay in treatment.

  NIH research Rand Corporation · Santa Monica, United States · NIH-11394389

• INSPIRE: Interprofessional simulation to improve care for birthing individuals with substance use disorder

  A team-based training program using webinars, in-person simulations, and AI-enhanced feedback aims to improve how healthcare providers care for pregnant people with substance use disorder in Utah.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11393772

• ELEVATE Center: Reducing maternal morbidity from substance use in Utah

  A nationwide center in Utah is testing how to improve care for pregnant and postpartum people with substance use disorders to reduce maternal illness and death.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11393765

• A flexible SUD genetic study tool using EHR data to refine substance use disorder phenotypes

  A new method will turn diverse electronic health record data into nuanced, probabilistic SUD phenotypes to help genetic studies and future clinical decision support.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11387854

• CARES Center: Patient-led Research to Improve Substance Use Disorder Care

  A patient-centered NIH grant is funding the CARES Center to partner with people affected by substance use disorder to shape and advance real-world care and treatment.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11378207

• New measure to capture substance-related problems in substance use trials

  Researchers are developing a new patient-centered way to quantify the negative effects of substance use to improve trials and treatments for substance use disorders.

  NIH research Mclean Hospital · Belmont, United States · NIH-11376502

• How HIV and cocaine affect brain immune cells (microglia)

  This project looks at whether cocaine helps HIV persist in brain immune cells and causes inflammation in people living with HIV.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11369183

• Opioid tapering outcomes for people with chronic pain and substance use disorder

  Using medical records from many hospitals, this project looks at what happens when opioids are reduced for people who have chronic pain and also a substance use disorder.

  NIH research Loyola University Chicago · Maywood, United States · NIH-11364654

• Community Action to End Substance Use Disorder (CARES Center)

  A new center that partners people with lived experience, families, and communities to co-design research and improve treatment and access for people with substance use disorder.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11362779

• ABC-SUD: A care-navigator program to help people start and stay in treatment for substance use disorders

  A Stanford-led program tests a care navigation approach to help people with substance use disorders start and keep engaging in treatment.

  NIH research Stanford University · Stanford, United States · NIH-11362381

• Genes that shape brain circuits linked to substance use-related behaviors

  Scientists are studying how certain genes influence brain circuits that control behaviors associated with substance use disorders, using advanced mouse models to map these connections.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11358441

• X chromosome differences may help explain why substance use disorders affect men and women differently

  This grant explores how genes on the X chromosome, and whether they escape inactivation, may influence why women and men experience substance use disorders differently.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11358357

• Optimizing Integrated Substance Use Disorder Treatment in Prisons

  Aims to find the most effective and cost-efficient parts of a prison-based substance use treatment program to help people in California prisons.

  NIH research Stanford University · Stanford, United States · NIH-11341547

• Helping SUD patients switch to less-harmful nicotine options during treatment

  Aimed at adults in substance use disorder treatment, the study explores whether guiding smokers to switch to non-combustible nicotine products can reduce health risks while people are in treatment.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11332840

• Understanding how adolescence problems with alcohol and behavior change as young adults grow up

  This study follows people who had adolescent substance use and behavioral problems into middle adulthood to see what factors help or hinder continued issues.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11332667

• A better way to supervise substance use disorder treatment programs

  Aimed at improving how supervisors support frontline counselors in community SUD programs to help clients and reduce staff burnout.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11326299

• Genetics of methamphetamine use disorder in Thailand (human-focused gene studies)

  A research project in Thailand will study how genetic factors relate to methamphetamine use disorder among people in treatment facilities and the community.

  NIH research Yale University · New Haven, United States · NIH-11323542

• A digital tool to support individuals recovering from substance use disorder

  This study is testing a helpful mobile app called Peer PLUS that connects people recovering from substance use disorder with their recovery coaches, making it easier for them to communicate, find resources, and track their progress on the road to recovery.

  NIH research Parkview Hospital, INC. · Fort Wayne, United States · NIH-11265787

• Improving identification methods for substance use disorders using genetic data

  This study is working on a new way to better identify substance use disorders by using health records and genetic information, which could help doctors find more accurate treatments and support for people struggling with these issues.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11263104

• Understanding the genetic factors behind substance use disorder

  This study is looking at how genes and the environment work together to affect substance use disorder, and it aims to find new ways to help people struggling with addiction by analyzing brain samples from both humans and fruit flies.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11262563

• Helping people in substance use treatment reduce tobacco harm

  This study is looking at ways to help people who are getting treatment for substance use disorders quit smoking by encouraging them to switch from regular cigarettes to safer options like e-cigarettes, making it easier for them to improve their health while tackling both issues at the same time.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11192931

• Identifying genes linked to behaviors in substance use disorders

  This study is looking at how our genes might affect behaviors related to substance use disorders by examining a brain circuit linked to anxiety, and it’s designed to help us understand more about the biology behind these challenges.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11192880

• Pink Cloud app to help people stay sober after treatment

  This project will see if the Pink Cloud smartphone app helps people with alcohol or drug addiction stay sober after completing treatment.

  NIH research Pink Cloud LLC · Culver City, UNITED STATES · NIH-11191566

• Improving treatment experiences for autistic adults with substance use disorder

  This study is creating helpful videos to train treatment providers on how to better communicate with autistic adults who are dealing with substance use issues, making sure they get the support they need during their recovery.

  NIH research Dfusion, INC. · Scotts Valley, United States · NIH-11178973

• Using health records to better identify and understand substance use disorders

  This project builds tools that use electronic health records to more accurately find people with substance use problems so researchers can study genetic contributors.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11171719

• Using synthetic cannabinoids to help reduce substance use disorder

  This study is exploring new, safer medications made from synthetic cannabinoids to help people dealing with substance use disorder, aiming to ease withdrawal symptoms without the risk of addiction.

  NIH research Syncanica Bio · Sacramento, United States · NIH-11146956

• Using wearables to track how moms respond when babies are distressed

  Researchers will use small wearable sensors to learn how mothers respond to their babies' distress to help prevent later substance use problems.

  NIH research University of Texas at Austin · Austin, United States · NIH-11146664

• How dopamine changes make cocaine addiction and learning harder

  This work explores how altered dopamine signals in the brain may make it harder for people with cocaine use disorder to learn new things and stop drug-seeking.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11144311

Related topics

Quick answers

How many Substance Use Disorder clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (10 trials), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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